Transcription factor Sp1

SP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SP1, 1SP2, 1VA1, 1VA2, 1VA3
Identifiers
Aliases	SP1, entrez:6667, Sp1 transcription factor
External IDs	OMIM: 189906; MGI: 98372; HomoloGene: 8276; GeneCards: SP1; OMA:SP1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,416,446 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,344,839 bp
RNA expression pattern
	Top expressed in
	nipple; ; trabecular bone; ; skin of hip; ; epithelium of colon; ; monocyte; ; vulva; ; skin of thigh; ; lactiferous duct; ; cardia; ; tonsil;
	Top expressed in
	Rostral migratory stream; ; vas deferens; ; human fetus; ; conjunctival fornix; ; internal carotid artery; ; hair follicle; ; ciliary body; ; skin of external ear; ; lacrimal gland; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; HMG box domain binding; transcription factor binding; histone deacetylase binding; metal ion binding; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; bHLH transcription factor binding; protein C-terminus binding; protein binding; histone acetyltransferase binding; nucleic acid binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA binding; double-stranded DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; core promoter sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding;
Cellular component	cytoplasm; nucleoplasm; protein-DNA complex; nucleus; transcription repressor complex;
Biological process	positive regulation of hydrogen sulfide biosynthetic process; rhythmic process; regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; viral process; regulation of transcription, DNA-templated; transcription, DNA-templated; snRNA transcription by RNA polymerase II; cellular response to insulin stimulus; positive regulation of transcription by RNA polymerase II; regulation of cholesterol biosynthetic process; positive regulation of gene expression; positive regulation of blood vessel endothelial cell migration; positive regulation of angiogenesis; positive regulation of vascular endothelial cell proliferation; response to hydroperoxide;
	Sources:Amigo / QuickGO
Orthologs
	6667
	20683
	ENSG00000185591
	ENSMUSG00000001280
	P08047
	O89090
	NM_001251825; NM_003109; NM_138473
	NM_013672
	NP_001238754; NP_003100; NP_612482
	NP_038700
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor Sp1, also known as specificity protein 1* is a protein that in humans is encoded by the SP1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185591 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001280 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Sp1 transcription factor".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185591 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001280 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Sp1 transcription factor".

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