Transdifferentiation

Transdifferentiation, also known as lineage reprogramming,[1] is the process in which one mature somatic cell is transformed into another mature somatic cell without undergoing an intermediate pluripotent state or progenitor cell type.[2] It is a type of metaplasia, which includes all cell fate switches, including the interconversion of stem cells. Current uses of transdifferentiation include disease modeling and drug discovery and in the future may include gene therapy and regenerative medicine.[3] The term 'transdifferentiation' was originally coined by Selman and Kafatos[4] in 1974 to describe a change in cell properties as cuticle producing cells became salt-secreting cells in silk moths undergoing metamorphosis.[5]

  1. ^ Orkin, S. H.; Zon, L. I. (2008). "Hematopoiesis: An Evolving Paradigm for Stem Cell Biology". Cell. 132 (4): 631–644. doi:10.1016/j.cell.2008.01.025. PMC 2628169. PMID 18295580.
  2. ^ Graf, T.; Enver, T. (2009). "Forcing cells to change lineages". Nature. 462 (7273): 587–594. Bibcode:2009Natur.462..587G. doi:10.1038/nature08533. PMID 19956253. S2CID 4417323.
  3. ^ Pournasr, B.; Khaloughi, K.; Salekdeh, G. H.; Totonchi, M.; Shahbazi, E.; Baharvand, H. (2011). "Concise Review: Alchemy of Biology: Generating Desired Cell Types from Abundant and Accessible Cells". Stem Cells. 29 (12): 1933–1941. doi:10.1002/stem.760. PMID 21997905.
  4. ^ Selman, Kelly; Kafatos, Fotis C. (1974-07-01). "Transdifferentiation in the labial gland of silk moths: is DNA required for cellular metamorphosis?". Cell Differentiation. 3 (2): 81–94. doi:10.1016/0045-6039(74)90030-X. PMID 4277742.
  5. ^ Selman, K.; Kafatos, F. C. (2013). "Transdifferentiation in the labial gland of silk moths: Is DNA required for cellular metamorphosis?". Cell Differentiation. 3 (2): 81–94. doi:10.1016/0045-6039(74)90030-x. PMID 4277742.