Translocator protein (TSPO) is an 18 kDa protein mainly found on the outer mitochondrial membrane.[5] It was first described as peripheral benzodiazepine receptor (PBR), a secondary binding site for diazepam, but subsequent research has found the receptor to be expressed throughout the body and brain.[6] In humans, the translocator protein is encoded by the TSPO gene.[7][8] It belongs to a family of tryptophan-rich sensory proteins. Regarding intramitochondrial cholesterol transport, TSPO has been proposed to interact with StAR (steroidogenic acute regulatory protein) to transport cholesterol into mitochondria, though evidence is mixed.[9]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000100300 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041736 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mokrov GV, Deeva OA, Gudasheva TA (2021). "The Ligands of Translocator Protein: Design and Biological Properties". Current Pharmaceutical Design. 27 (2): 217–237. doi:10.2174/1381612826666200903122025. PMID 32881658. S2CID 221498255.
- ^ Papadopoulos V, Baraldi M, Guilarte TR, Knudsen TB, Lacapère JJ, Lindemann P, et al. (August 2006). "Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function". Trends in Pharmacological Sciences. 27 (8): 402–409. doi:10.1016/j.tips.2006.06.005. PMID 16822554.
- ^ Chang YJ, McCabe RT, Rennert H, Budarf ML, Sayegh R, Emanuel BS, et al. (1992). "The human "peripheral-type" benzodiazepine receptor: regional mapping of the gene and characterization of the receptor expressed from cDNA". DNA and Cell Biology. 11 (6): 471–480. doi:10.1089/dna.1992.11.471. PMID 1326278.
- ^ Riond J, Mattei MG, Kaghad M, Dumont X, Guillemot JC, Le Fur G, et al. (January 1991). "Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor". European Journal of Biochemistry. 195 (2): 305–311. doi:10.1111/j.1432-1033.1991.tb15707.x. PMID 1847678.
- ^ Bogan RL, Davis TL, Niswender GD (April 2007). "Peripheral-type benzodiazepine receptor (PBR) aggregation and absence of steroidogenic acute regulatory protein (StAR)/PBR association in the mitochondrial membrane as determined by bioluminescence resonance energy transfer (BRET)". The Journal of Steroid Biochemistry and Molecular Biology. 104 (1–2): 61–67. doi:10.1016/j.jsbmb.2006.10.007. PMID 17197174. S2CID 24634653.