Transplant glomerulopathy

Transplant glomerulopathy
Micrograph showing a glomerulus with changes characteristic of a transplant glomerulopathy. PAS stain.
SpecialtyNephrology

Transplant glomerulopathy (TG) is a morphologic lesion of renal allografts that is histologically identified by glomerular basement membrane (GBM) duplication and/or multilayering.[1] Proteinuria, hypertension, and deteriorating graft function are the hallmarks of TG.[2]

Acute rejection, pre-transplant antibody levels, and de novo HLA antibodies are all linked to TG. There are further risks associated with HLA class II and/or donor-specific antibodies.[2]

Five years after transplant, TG is present in 5–10% of renal allografts; in rare cases, protocol biopsies may reveal TG as a subclinical finding. With chronic alloantibody-mediated injury, the lesion is particularly associated with a poor prognosis for the outcome of the graft.[3]

  1. ^ Haas, Mark (2015). "Transplant Glomerulopathy". Journal of the American Society of Nephrology. 26 (6). Ovid Technologies (Wolters Kluwer Health): 1235–1237. doi:10.1681/asn.2014090945. ISSN 1046-6673. PMC 4446884. PMID 25388221.
  2. ^ a b Fotheringham, James; Angel, Carole A.; McKane, William (July 10, 2009). "Transplant Glomerulopathy: Morphology, Associations and Mechanism". Nephron Clinical Practice. 113 (1). S. Karger AG: c1–c7. doi:10.1159/000228069. ISSN 1660-2110. PMID 19590229.
  3. ^ Cite error: The named reference Importance of Ultrastructural Examination was invoked but never defined (see the help page).