Transporter associated with antigen processing

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Identifiers
SymbolTAP1
Alt. symbolsABCB2
NCBI gene6890
HGNC43
OMIM170260
RefSeqNM_000593
UniProtQ03518
Other data
LocusChr. 6 p21.3
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StructuresSwiss-model
DomainsInterPro
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Identifiers
SymbolTAP2
Alt. symbolsABCB3
NCBI gene6891
HGNC44
OMIM170261
RefSeqNM_000544
UniProtQ03519
Other data
LocusChr. 6 p21.3
Search for
StructuresSwiss-model
DomainsInterPro

Transporter associated with antigen processing (TAP) protein complex belongs to the ATP-binding-cassette transporter family.[1] It delivers cytosolic peptides into the endoplasmic reticulum (ER), where they bind to nascent MHC class I molecules.[2]

The TAP structure is formed of two proteins: TAP-1 and TAP-2, which have one hydrophobic region and one ATP-binding region each. They assemble into a heterodimer, which results in a four-domain transporter.[3]

  1. ^ Daumke O, Knittler MR (2001). "Functional asymmetry of the ATP-binding-cassettes of the ABC transporter TAP is determined by intrinsic properties of the nucleotide binding domains". Eur. J. Biochem. 268 (17): 4776–86. doi:10.1046/j.1432-1327.2001.02406.x. PMID 11532014.
  2. ^ Suh WK, Cohen-Doyle MF, Fruh K, Wang K, Peterson PA, Williams DB (1994). "Interaction of MHC class I molecules with the transporter associated with antigen processing". Science. 264 (5163): 1322–6. Bibcode:1994Sci...264.1322S. doi:10.1126/science.8191286. PMID 8191286.
  3. ^ Janeway CA, Travers P, Walport M, Shlomchik M (2001). "Chapter 5, Antigen Presentation to T-lymphocytes". In Janeway, Charles (ed.). Immunobiology: the immune system in health and disease (5th ed.). New York: Garland. ISBN 0-8153-3642-X.