Clinical data | |
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Trade names | Travatan, Izba, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a602027 |
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Routes of administration | Topical eye drops |
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Pharmacokinetic data | |
Metabolism | Activation by ester hydrolysis, deactivation by beta oxidation, OH-oxidation, double bond reduction |
Onset of action | 2 hours |
Elimination half-life | 1.5 hours (in aqueous fluid) 45 minutes (terminal) |
Duration of action | ≥ 24 hours |
Excretion | Mainly via kidney |
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ECHA InfoCard | 100.207.141 |
Chemical and physical data | |
Formula | C26H35F3O6 |
Molar mass | 500.555 g·mol−1 |
3D model (JSmol) | |
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Travoprost, sold under the brand name Travatan among others, is a medication used to treat high pressure inside the eye including glaucoma.[4] Specifically it is used for open angle glaucoma when other agents are not sufficient.[5][4] It is used as an eye drop.[4] Effects generally occur within two hours.[4]
Common side effects include red eyes, blurry vision, eye pain, dry eyes, and change in color of the eyes.[4][5] Other significant side effects may include cataracts.[5] Use during pregnancy or breastfeeding is generally not recommended.[5] It is a prostaglandin analog and works by increasing the outflow of aqueous fluid from the eyes.[4]
Travoprost was approved for medical use in the United States and in the European Union in 2001.[4][3] It is available as a generic medication in the United Kingdom.[5] In 2020, it was the 304th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[6][7]