Treponema pallidum

Treponema pallidum
Scientific classification
Domain:	Bacteria
Phylum:	Spirochaetota
Class:	Spirochaetia
Order:	Spirochaetales
Family:	Treponemataceae
Genus:	Treponema
Species:	T. pallidum
Binomial name
Treponema pallidum Schaudinn & Hoffmann, 1905

Treponema pallidum, formerly known as Spirochaeta pallida, is a microaerophilic, gram-negative, spirochaete bacterium with subspecies that cause the diseases syphilis, bejel (also known as endemic syphilis), and yaws.^[1] It is known to be transmitted only among humans and baboons.^[2] T. pallidum can enter the host through mucosal membranes or open lesions in the skin and is primarily spread through sexual contact.^[3] It is a helically coiled microorganism usually 6–15 μm long and 0.1–0.2 μm wide. T. pallidum's lack of both a tricarboxylic acid cycle and processes for oxidative phosphorylation results in minimal metabolic activity.^[4] As a chemoorganoheterotroph, Treponema pallidum is an obligate parasite that acquires its glucose carbon source from its host. Glucose can be used not only as a primary carbon source but also in glycolytic mechanisms to generate ATP needed to power the bacterium given its minimal genome.^[5] The treponemes have cytoplasmic and outer membranes. Using light microscopy, treponemes are visible only by using dark-field illumination. T. pallidum consists of three subspecies, T. p. pallidum, T. p. endemicum, and T. p. pertenue, each of which has a distinct related disorder. The ability of T. pallidum to avoid host immune defenses has allowed for stealth pathogenicity.^[6] The unique outer membrane structure and minimal expression of surface proteins of T. pallidum has made vaccine development difficult. Treponema pallidum can be treated with high efficacy by antibiotics that inhibit bacterial cell wall synthesis such as the beta-lactam antimicrobial penicillin-G.^[7]