Triclosan

Not to be confused with triclocarban.
Triclosan
Names
Preferred IUPAC name
5-Chloro-2-(2,4-dichlorophenoxy)phenol
Other names
2,4,4′-Trichloro-2′-hydroxydiphenyl ether
5-Chloro-(2,4-dichlorophenoxy)phenol
Trichloro-2′-hydroxydiphenyl ether
CH-3565
Lexol 300
Irgasan DP 300
Ster-Zac
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.020.167 Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H checkY
    Key: XEFQLINVKFYRCS-UHFFFAOYSA-N checkY
  • InChI=1/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H
    Key: XEFQLINVKFYRCS-UHFFFAOYAS
  • Clc2cc(Cl)ccc2Oc1ccc(Cl)cc1O
Properties
C12H7Cl3O2
Molar mass 289.54 g·mol−1
Appearance White solid
Density 1.49 g/cm3
Melting point 55–57 °C (131–135 °F; 328–330 K)
Boiling point 120 °C (248 °F; 393 K)
Pharmacology
D08AE04 (WHO) D09AA06 (WHO) (medicated dressing)
Hazards
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g. chloroformFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
2
1
0
Flash point 162.2 °C (324.0 °F; 435.3 K)
Safety data sheet (SDS) MSDS
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Triclosan (sometimes abbreviated as TCS) is an antibacterial and antifungal agent present in some consumer products, including toothpaste, soaps, detergents, toys, and surgical cleaning treatments. It is similar in its uses and mechanism of action to triclocarban. Its efficacy as an antimicrobial agent, the risk of antimicrobial resistance, and its possible role in disrupted hormonal development remains controversial. Additional research seeks to understand its potential effects on organisms and environmental health.

Triclosan was developed in 1966.[1] A 2006 study recommended showering with 2% triclosan as a regimen in surgical units to rid patients' skin of methicillin-resistant Staphylococcus aureus (MRSA).[2]

  1. ^ Boyce JM, Pittet D, Healthcare Infection Control Practices Advisory Committee, HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force (25 October 2002). "Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America/Association for Professionals in Infection Control/Infectious Diseases Society of America". MMWR. Recommendations and Reports. 51 (RR-16): 1–45, quiz CE1–4. PMID 12418624.
  2. ^ Coia J, Duckworth G, Edwards D, Farrington M, Fry C, Humphreys H, Mallaghan C, Tucker D, Joint Working Party of the British Society of Antimicrobial Chemotherapy, Hospital Infection S, Infection Control Nurses Association (2006). "Guidelines for the control and prevention of meticillin-resistant Staphylococcus aureus (MRSA) in healthcare facilities". Journal of Hospital Infection. 63: S1–44. doi:10.1016/j.jhin.2006.01.001. PMID 16581155.