Trihexyphenidyl

Trihexyphenidyl
Clinical data
Trade names	Artane, Parkin, Pacitane, Hexymer
AHFS/Drugs.com	Monograph
MedlinePlus	a682160
License data	US DailyMed: Trihexyphenidyl;
Pregnancy; category	AU: B1; ;
Routes of; administration	Oral, as tablet or elixir
ATC code	N04AA01 (WHO) ;
Legal status
Legal status	BR: Class B1 (Psychoactive drugs); US: ℞-only;
Pharmacokinetic data
Elimination half-life	3.3-4.1 hours
Identifiers
	IUPAC name (RS)-1-Cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol;
CAS Number	144-11-6 ;
PubChem CID	5572;
IUPHAR/BPS	7315;
DrugBank	DB00376 ;
ChemSpider	5371 ;
UNII	6RC5V8B7PO;
KEGG	D08638 ;
ChEMBL	ChEMBL1490 ;
CompTox Dashboard (EPA)	DTXSID4023705 ;
ECHA InfoCard	100.005.105
Chemical and physical data
Formula	C20H31NO
Molar mass	301.474 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC(c1ccccc1)(CCN2CCCCC2)C3CCCCC3;
	InChI InChI=1S/C20H31NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2 ; Key:HWHLPVGTWGOCJO-UHFFFAOYSA-N ;
	(verify)

Trihexyphenidyl (THP, benzhexol, trihex, marketed as Artane and others) is an antispasmodic drug used to treat stiffness, tremors, spasms, and poor muscle control. It is an agent of the antimuscarinic class and is often used in management of Parkinson's disease. It was approved by the FDA for the treatment of Parkinson's in the US in 2003.^[2]^[3]

It is on the World Health Organization's List of Essential Medicines.^[4]

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ "TGA eBS - Product and Consumer Medicine Information Licence". www.ebs.tga.gov.au. Retrieved 2020-08-20.
^ "New Drug Application Approval Notice" (PDF). U.S. Food and Drug Administration. 2003-05-25. Retrieved 2020-08-20.
^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[2] "TGA eBS - Product and Consumer Medicine Information Licence". www.ebs.tga.gov.au. Retrieved 2020-08-20.

[3] "New Drug Application Approval Notice" (PDF). U.S. Food and Drug Administration. 2003-05-25. Retrieved 2020-08-20.

[WHO22nd-4] World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

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