Trilaciclib

Trilaciclib
Clinical data
Pronunciation/ˌtraɪləˈsaɪklɪb/
TRY-lə-SY-klib
Trade namesCosela
AHFS/Drugs.comFDA Professional Drug Information
License data
Routes of
administration		Intravenous
Drug classCyclin-dependent kinase (CDK) inhibitor
ATC code
Legal status
Legal status
Identifiers
  • 4-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]spiro[1,3,5,11-tetrazatricyclo[7.4.0.02,7]trideca-2,4,6,8-tetraene-13,1'-cyclohexane]-10-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC24H30N8O
Molar mass446.559 g·mol−1
3D model (JSmol)
  • CN1CCN(CC1)C1=CN=C(NC2=NC3=C(C=C4N3C3(CCCCC3)CNC4=O)C=N2)C=C1
  • InChI=1S/C24H30N8O/c1-30-9-11-31(12-10-30)18-5-6-20(25-15-18)28-23-26-14-17-13-19-22(33)27-16-24(7-3-2-4-8-24)32(19)21(17)29-23/h5-6,13-15H,2-4,7-12,16H2,1H3,(H,27,33)(H,25,26,28,29)
  • Key:PDGKHKMBHVFCMG-UHFFFAOYSA-N

Trilaciclib, sold under the brand name Cosela, is a medication used to reduce the frequency of chemotherapy-induced bone marrow suppression.[1][2][3][4]

The most common side effects include fatigue; low levels of calcium, potassium and phosphate; increased levels of an enzyme called aspartate aminotransferase; headache; and infection in the lungs (pneumonia).[2]

Trilaciclib may help protect bone marrow cells from damage caused by chemotherapy by inhibiting cyclin-dependent kinase 4/6, a type of enzyme.[2] Trilaciclib is the first therapy in its class and was approved for medical use in the United States in February 2021.[2][5] The U.S. Food and Drug Administration considers it to be a first-in-class medication.[6]

Chemotherapy drugs are designed to kill cancer cells but can damage normal tissues as well.[2] The bone marrow is particularly susceptible to chemotherapy damage.[2] The bone marrow makes red blood cells, white blood cells, and platelets (small fragments in the blood) that transport oxygen, fight infection, and stop bleeding.[2] When damaged, the bone marrow produces fewer of these cells, leading to fatigue, increased risk of infection, and bleeding, among other problems.[2] Trilaciclib may help protect the normal bone marrow cells from the harmful effects of chemotherapy.[2]

  1. ^ a b "Cosela- trilaciclib injection, powder, lyophilized, for solution". DailyMed. Retrieved 17 June 2021.
  2. ^ a b c d e f g h i j "FDA Approves Drug to Reduce Bone Marrow Suppression Caused by Chemotherapy". U.S. Food and Drug Administration (FDA) (Press release). 12 February 2021. Retrieved 12 February 2021. Public Domain This article incorporates text from this source, which is in the public domain.
  3. ^ "FDA Approves G1 Therapeutics' Cosela (trilaciclib): The First and Only Myeloprotection Therapy to Decrease the Incidence of Chemotherapy-Induced Myelosuppression" (Press release). G1 Therapeutics. 12 February 2021. Retrieved 12 February 2021 – via GlobeNewswire.
  4. ^ Dhillon S (May 2021). "Trilaciclib: First Approval". Drugs. 81 (7): 867–874. doi:10.1007/s40265-021-01508-y. PMID 33861388. S2CID 233258487.
  5. ^ "Drug Approval Package: Cosela". U.S. Food and Drug Administration (FDA). 12 March 2021. Retrieved 13 September 2021.
  6. ^ Advancing Health Through Innovation: New Drug Therapy Approvals 2021 (PDF). U.S. Food and Drug Administration (FDA) (Report). 13 May 2022. Archived from the original on 6 December 2022. Retrieved 22 January 2023. Public Domain This article incorporates text from this source, which is in the public domain.