 Trimethoprim (top) and sulfamethoxazole (bottom) | |
| Combination of | |
|---|---|
| Sulfamethoxazole | Sulfonamide antibiotic |
| Trimethoprim | Dihydrofolate reductase inhibitor |
| Clinical data | |
| Trade names | Bactrim, Cotrim, Septra, others |
| Other names | TMP/SMX, cotrimoxazole, Co-trimoxazole (BAN UK) |
| AHFS/Drugs.com | Monograph |
| License data | |
| Pregnancy category |
|
| Routes of administration | oral, intravenous[2] |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| (verify) | |
Trimethoprim/sulfamethoxazole, sold under the brand name Bactrim among others, is a fixed-dose combination antibiotic medication used to treat a variety of bacterial infections.[2] It consists of one part trimethoprim to five parts sulfamethoxazole.[7] It is used to treat urinary tract infections, methicillin-resistant Staphylococcus aureus (MRSA) skin infections, travelers' diarrhea, respiratory tract infections, and cholera, among others.[2][7] It is used both to treat and prevent pneumocystis pneumonia and toxoplasmosis in people with HIV/AIDS and other causes of immunosuppression.[2] It can be given orally (swallowed by mouth) or intravenous infusion (slowly injected into a vein with an IV).[2]
Trimethoprim/sulfamethoxazole is on the World Health Organization's List of Essential Medicines.[8] It is available as a generic medication.[7][9] In 2021, it was the 122nd most commonly prescribed medication in the United States, with more than 4 million prescriptions.[10][11][United States-centric]
- ^ "Sulfamethoxazole / trimethoprim Use During Pregnancy". Drugs.com. 8 March 2019. Archived from the original on 6 September 2015. Retrieved 15 April 2020.
- ^ a b c d e "Co-trimoxazole". The American Society of Health-System Pharmacists. Archived from the original on 6 September 2015. Retrieved 1 August 2015.
- ^ "Bactrim DS tablet blister pack". Therapeutic Goods Administration (TGA). Archived from the original on 29 December 2021. Retrieved 28 December 2021.
- ^ "TGA eBS - Product and Consumer Medicine Information Licence". Archived from the original on 29 December 2021. Retrieved 29 December 2021.
- ^ "Co-Trimoxazole 80 mg/400 mg Tablets - Summary of Product Characteristics (SmPC)". (emc). 1 August 2021. Archived from the original on 29 December 2021. Retrieved 28 December 2021.
- ^ "Bactrim DS- sulfamethoxazole and trimethoprim tablet Bactrim- sulfamethoxazole and trimethoprim tablet". DailyMed. Archived from the original on 29 December 2021. Retrieved 28 December 2021.
- ^ a b c Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 105. ISBN 9781284057560.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
- ^ Cite error: The named reference
Brown2019was invoked but never defined (see the help page). - ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ^ "Sulfamethoxazole; Trimethoprim - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.