Tropomyosin receptor kinase A

NTRK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HE7, 1SHC, 1WWA, 1WWW, 2IFG, 4AOJ, 4F0I, 4GT5, 4CRP, 4PMM, 4PMP, 4PMS, 4PMT, 4YNE, 4YPS
Identifiers
Aliases	NTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, neurotrophic receptor tyrosine kinase 1
External IDs	OMIM: 191315; MGI: 97383; HomoloGene: 1898; GeneCards: NTRK1; OMA:NTRK1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.1 Start 156,815,640 bp[1] End 156,881,850 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 38.62 cM Start 87,685,551 bp[2] End 87,702,469 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spinal ganglia apex of heart testicle gonad right auricle left uterine tube pons muscle layer of sigmoid colon left ventricle body of uterus Top expressed in lumbar spinal ganglion superior cervical ganglion neural tube trigeminal ganglion glossopharyngeal ganglion embryo embryo ganglion of vagus nerve superior ganglion of vagus nerve superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neurotrophin binding GPI-linked ephrin receptor activity neurotrophin receptor activity kinase activity ATP binding protein kinase activity kinase binding transferase activity protein homodimerization activity protein binding nucleotide binding nerve growth factor binding neurotrophin p75 receptor binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity nerve growth factor receptor activity Cellular component cytoplasm endosome membrane late endosome membrane cell surface integral component of membrane late endosome early endosome membrane receptor complex plasma membrane axon soma early endosome integral component of plasma membrane dendrite cytoplasmic vesicle Golgi membrane endosome membrane protein-containing complex recycling endosome recycling endosome membrane Biological process negative regulation of neuron apoptotic process positive regulation of protein phosphorylation positive regulation of Ras protein signal transduction positive regulation of programmed cell death behavioral response to formalin induced pain detection of temperature stimulus involved in sensory perception of pain protein phosphorylation circadian rhythm positive regulation of ERK1 and ERK2 cascade B cell differentiation response to ethanol innervation negative regulation of cell population proliferation response to nicotine positive regulation of GTPase activity positive regulation of synaptic transmission, glutamatergic response to nutrient levels learning or memory protein autophosphorylation negative regulation of neuron death detection of mechanical stimulus involved in sensory perception of pain cell differentiation neurotrophin TRK receptor signaling pathway phosphorylation cellular response to nicotine olfactory nerve development response to electrical stimulus Sertoli cell development mechanoreceptor differentiation nervous system development positive regulation of angiogenesis positive regulation of NF-kappaB transcription factor activity response to axon injury sensory perception of pain response to radiation phosphatidylinositol-mediated signaling sympathetic nervous system development ephrin receptor signaling pathway cellular response to growth factor stimulus ageing response to hydrostatic pressure response to activity axon guidance multicellular organism development axonogenesis involved in innervation positive regulation of neuron projection development programmed cell death involved in cell development positive regulation of synapse assembly transmembrane receptor protein tyrosine kinase signaling pathway microtubule-based movement peptidyl-tyrosine phosphorylation peptidyl-tyrosine autophosphorylation nerve growth factor signaling pathway cellular response to nerve growth factor stimulus positive regulation of phosphatidylinositol 3-kinase signaling negative regulation of apoptotic process regulation of MAPK cascade positive regulation of MAPK cascade cellular response to amyloid-beta Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4914 18211 Ensembl ENSG00000198400 ENSMUSG00000028072 UniProt P04629 Q3UFB7 RefSeq (mRNA) NM_002529 NM_001007792 NM_001012331 NM_001033124 RefSeq (protein) NP_001007793 NP_001012331 NP_002520 NP_001028296 Location (UCSC) Chr 1: 156.82 – 156.88 Mb Chr 3: 87.69 – 87.7 Mb PubMed search [3] [4]
Wikidata
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Tropomyosin receptor kinase A (TrkA),^[5] also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming tyrosine kinase protein is a protein that in humans is encoded by the NTRK1 gene.^[6]

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself (autophosphorylation) and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain with anhidrosis, self-mutilating behaviors, intellectual disability and/or cognitive impairment and certain cancers. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.^[7]