Tryptophan hydroxylase

tryptophan 5-monooxygenase
tryptophan 5-monooxygenase monomer, Human
Identifiers
EC no.1.14.16.4
CAS no.9037-21-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)
Identifiers
SymbolTPH1
Alt. symbolsTPRH, TPH
NCBI gene7166
HGNC12008
OMIM191060
PDB1MLW
RefSeqNM_004179
UniProtP17752
Other data
EC number1.14.16.4
LocusChr. 11 p15.3-p14
Search for
StructuresSwiss-model
DomainsInterPro
tryptophan hydroxylase 2
Identifiers
SymbolTPH2
NCBI gene121278
HGNC20692
OMIM607478
RefSeqNM_173353
UniProtQ8IWU9
Other data
LocusChr. 12 q15
Search for
StructuresSwiss-model
DomainsInterPro

Tryptophan hydroxylase (TPH) is an enzyme (EC 1.14.16.4) involved in the synthesis of the monoamine neurotransmitter serotonin. Tyrosine hydroxylase, phenylalanine hydroxylase, and tryptophan hydroxylase together constitute the family of biopterin-dependent aromatic amino acid hydroxylases. TPH catalyzes the following chemical reaction

L-tryptophan + tetrahydrobiopterin + O2 5-Hydroxytryptophan + dihydrobiopterin + H2O

It employs one additional cofactor, iron.