Tse Wen Chang

Tse Wen Chang
張子文
Born (1947-08-25) August 25, 1947 (age 77)
Zhongli District, Taoyuan County, Taiwan
EducationNational Tsing Hua University (BS, MS)
Harvard University (PhD)
Known forXolair
anti-IgE therapy
Antibody microarray
Scientific career
FieldsImmunology, Biomedicine, Biotechnology
InstitutionsNational Tsing Hua University
Tanox, Inc.
Academia Sinica
Immunwork, Inc.
Doctoral advisorAlfred L. Goldberg

Tse Wen Chang (Chinese: 張子文; pinyin: Zhāng Zǐwén, born August 25, 1947) is a Taiwanese immunologist. His early research involving the Immunoglobulin E (IgE) pathway and antibody-based therapeutics lead to the development of omalizumab (also known as Xolair), a medication that has been approved for the treatment of severe allergic asthma and severe chronic spontaneous urticaria.[1] Chang is a cofounder of Tanox, a biopharmaceutical company specialized in anti-IgE therapies for the treatment of allergic diseases.[2]

After Tanox's tripartite partnership with Genentech and Novartis was made in 1996, Chang returned to his alma mater, the National Tsing Hua University in Taiwan and served as the Dean (1996–1999) of the College of Life Sciences.[3] Chang was appointed by the Taiwanese government as President of the Development Center for Biotechnology (DCB) in 2000, and served as a Science and Technology Advisor of the Executive Yuan from 2002 to 2006.[4] From 2006 to 2016, he was tenured as Distinguished Research Fellow at the Genomics Research Center, Academia Sinica.[5] He founded Immunwork, Inc. in 2014.

  1. ^ Chang, Tse Wen; Chen, Christina; Lin, Chien-Jen; Metz, Martin; Church, Martin K.; Maurer, Marcus (2015-02-01). "The potential pharmacologic mechanisms of omalizumab in patients with chronic spontaneous urticaria". Journal of Allergy and Clinical Immunology. 135 (2): 337–342.e2. doi:10.1016/j.jaci.2014.04.036. PMID 24948369. S2CID 13090739.
  2. ^ "Tanox, Inc. – Company Profile, Information, Business Description, History, Background Information on Tanox, Inc". Reference for Business. Advameg, Inc. Retrieved 3 May 2017.
  3. ^ "2008年：張子文校友". National Tsing Hua University. Retrieved 3 May 2017.
  4. ^ "張子文 (Dr. Tse-Wen Chang)". Board of Science and Technology, Executive Yuan. Retrieved 3 May 2017.
  5. ^ "Chang, Tse Wen". Genomics Research Center, Academia Sinica. Retrieved 3 May 2017.