Tumor necrosis factor receptor 2

TNFRSF1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CA9, 3ALQ
Identifiers
Aliases	TNFRSF1B, CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR, tumor necrosis factor receptor superfamily member 1B, TNF receptor superfamily member 1B
External IDs	OMIM: 191191; MGI: 1314883; HomoloGene: 829; GeneCards: TNFRSF1B; OMA:TNFRSF1B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 12,166,991 bp[1] End 12,209,228 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E1|4 78.17 cM Start 144,940,033 bp[2] End 144,973,440 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood spleen appendix tendon of biceps brachii right lung lymph node subcutaneous adipose tissue periodontal fiber Top expressed in decidua stroma of bone marrow aortic valve granulocyte gastrula blood mesenteric lymph nodes spleen ascending aorta internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase binding tumor necrosis factor-activated receptor activity tumor necrosis factor binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane varicosity extracellular region axon neuronal cell body perinuclear region of cytoplasm membrane raft nucleus specific granule membrane tumor necrosis factor receptor superfamily complex Biological process extrinsic apoptotic signaling pathway RNA destabilization cellular response to growth factor stimulus positive regulation of membrane protein ectodomain proteolysis human ageing multicellular organism development cell surface receptor signaling pathway response to lipopolysaccharide regulation of cell population proliferation immune response intrinsic apoptotic signaling pathway in response to DNA damage apoptotic signaling pathway inflammatory response cellular response to lipopolysaccharide negative regulation of inflammatory response apoptotic process tumor necrosis factor-mediated signaling pathway neutrophil degranulation negative regulation of cysteine-type endopeptidase activity involved in apoptotic process cytokine-mediated signaling pathway aortic valve development pulmonary valve development negative regulation of extracellular matrix constituent secretion negative regulation of cardiac muscle hypertrophy positive regulation of apoptotic process involved in morphogenesis regulation of T cell cytokine production regulation of myelination regulation of T cell proliferation regulation of neuroinflammatory response cellular response to tumor necrosis factor positive regulation of myelination positive regulation of oligodendrocyte differentiation negative regulation of cell death negative regulation of neuroinflammatory response glial cell-neuron signaling negative regulation of neuron death regulation of RNA biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7133 21938 Ensembl ENSG00000028137 ENSMUSG00000028599 UniProt P20333 P25119 RefSeq (mRNA) NM_001066 NM_011610 RefSeq (protein) NP_001057 NP_035740 Location (UCSC) Chr 1: 12.17 – 12.21 Mb Chr 4: 144.94 – 144.97 Mb PubMed search [3] [4]
Wikidata
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Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and CD120b, is one of two membrane receptors that binds tumor necrosis factor-alpha (TNFα).^[5][6] Like its counterpart, tumor necrosis factor receptor 1 (TNFR1), the extracellular region of TNFR2 consists of four cysteine-rich domains which allow for binding to TNFα.^[7][8] TNFR1 and TNFR2 possess different functions when bound to TNFα due to differences in their intracellular structures, such as TNFR2 lacking a death domain (DD).^[7]