Type II cytokine receptor

Type II cytokine receptor
Identifiers
SymbolType II cytokine receptor
Pfam clanCL0159
Membranome2
Interferon gamma receptor
Identifiers
SymbolIFNGR1
PfamPF07140
InterProIPR021126
SCOP21fg9 / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Interferon-alpha/beta receptor, fibronectin type III
Identifiers
SymbolInterfer-bind
PfamInterfer-bind
InterProIPR015373
SCOP21n6u / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Type II cytokine receptors, also commonly known as class II cytokine receptors, are transmembrane proteins that are expressed on the surface of certain cells. They bind and respond to a select group of cytokines including interferon type I, interferon type II, interferon type III.[1] and members of the interleukin-10 family[2][3] These receptors are characterized by the lack of a WSXWS motif which differentiates them from type I cytokine receptors.[4]

  1. ^ Krey K, Babnis AW, Pichlmair A (October 2020). "System-Based Approaches to Delineate the Antiviral Innate Immune Landscape". Viruses. 12 (10): 1196. doi:10.3390/v12101196. PMC 7589202. PMID 33096788.
  2. ^ Cite error: The named reference pmid11481447 was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference pmid12521379 was invoked but never defined (see the help page).
  4. ^ Stanifer ML, Pervolaraki K, Boulant S (March 2019). "Differential Regulation of Type I and Type III Interferon Signaling". International Journal of Molecular Sciences. 20 (6): 1445. doi:10.3390/ijms20061445. PMC 6471306. PMID 30901970.