This article is missing information about pfam box for the actual catalytic domain; member of breaking-rejoining enzyme (BRE) superfamily; link between BRE and AraC homeobox per ECOD.(February 2021) |
DNA topoisomerase I, N-terminal (non-catalytic), viral | |||||||||
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Identifiers | |||||||||
Symbol | VirDNA-topo-I_N | ||||||||
Pfam | PF09266 | ||||||||
InterPro | IPR015346 | ||||||||
SCOP2 | 1vcc / SCOPe / SUPFAM | ||||||||
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In molecular biology Type I topoisomerases are enzymes that cut one of the two strands of double-stranded DNA, relax the strand, and reanneal the strand. They are further subdivided into two structurally and mechanistically distinct topoisomerases: type IA and type IB.
Historically, type IA topoisomerases are referred to as prokaryotic topo I, while type IB topoisomerases are referred to as eukaryotic topoisomerase. This distinction, however, no longer applies as type IA and type IB topoisomerases exist in all domains of life.
Functionally, these subclasses perform very specialized functions. Prokaryotic topoisomerase I (topo IA) can only relax negative supercoiled DNA, whereas eukaryotic topoisomerase I (topo IB) can introduce positive supercoils, separating the DNA of daughter chromosomes after DNA replication, and relax DNA.