Type VII secretion system

Type VII secretion systems are bacterial secretion systems first observed in the phyla Actinomycetota and Bacillota. Bacteria use such systems to transport, or secrete, proteins into the environment.[1] The bacterial genus Mycobacterium uses type VII secretion systems (T7SS) to secrete proteins across their cell envelope.[2] The first T7SS system discovered was the ESX-1 System.[2]

T7SS has been studied as a virulence factor associated with the ESX-1 system in Mycobacterium tuberculosis.[2] These secretion systems are often found in gram-positive bacteria. Type VII secretion systems are necessary in Mycobacterium because of their impermeable membrane.[3] The RD1 locus or Gene for Type VII secretion can create a lytic effect through ESX-1 transport.[4]

  1. ^ Spencer BL, Doran KS (July 2022). "Evolving understanding of the type VII secretion system in Gram-positive bacteria". PLOS Pathogens. 18 (7): e1010680. doi:10.1371/journal.ppat.1010680. PMC 9333272. PMID 35901012.
  2. ^ a b c Houben EN, Korotkov KV, Bitter W (August 2014). "Take five - Type VII secretion systems of Mycobacteria". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. Protein trafficking and secretion in bacteria. 1843 (8): 1707–1716. doi:10.1016/j.bbamcr.2013.11.003. PMID 24263244.
  3. ^ Beckham KS, Ciccarelli L, Bunduc CM, Mertens HD, Ummels R, Lugmayr W, et al. (April 2017). "Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis". Nature Microbiology. 2 (6): 17047. doi:10.1038/nmicrobiol.2017.47. hdl:1871.1/350ffd47-20da-4c24-8b09-ce4ce2872e69. PMID 28394313. S2CID 10602253.
  4. ^ Famelis N, Rivera-Calzada A, Degliesposti G, Wingender M, Mietrach N, Skehel JM, et al. (December 2019). "Architecture of the mycobacterial type VII secretion system". Nature. 576 (7786): 321–325. Bibcode:2019Natur.576..321F. doi:10.1038/s41586-019-1633-1. PMC 6914368. PMID 31597161.