Tyrosine-protein kinase BLK

BLK
Identifiers
Aliases	BLK, MODY11, BLK proto-oncogene, Src family tyrosine kinase
External IDs	OMIM: 191305; MGI: 88169; HomoloGene: 1297; GeneCards: BLK; OMA:BLK - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	11,564,599 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	63,654,486 bp
RNA expression pattern
	Top expressed in
	spleen; ; testicle; ; lymph node; ; granulocyte; ; appendix; ; mucosa of transverse colon; ; bone marrow cells; ; blood; ; tonsil; ; stromal cell of endometrium;
	Top expressed in
	spleen; ; mesenteric lymph nodes; ; blood; ; granulocyte; ; thymus; ; subcutaneous adipose tissue; ; bone marrow; ; Ileal epithelium; ; axillary lymph node; ; tunica adventitia of aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; non-membrane spanning protein tyrosine kinase activity; kinase activity; protein binding; protein tyrosine kinase activity; signaling receptor binding; ATP binding;
Cellular component	membrane; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; cytosol;
Biological process	B cell receptor signaling pathway; cell differentiation; intracellular signal transduction; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; protein phosphorylation; regulation of cell population proliferation; peptidyl-tyrosine autophosphorylation; innate immune response; positive regulation of insulin secretion; cell migration; regulation of B cell receptor signaling pathway; peptidyl-tyrosine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	640
	12143
	ENSG00000136573; ENSG00000285369
	ENSMUSG00000014453
	P51451
	P16277
	NM_001715; NM_001330465
	NM_007549
	NP_001317394; NP_001706
	NP_031575
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase BLK, also known as B lymphocyte kinase, is a non-receptor tyrosine kinase that in humans is encoded by the BLK gene.^[5]^[6] It is of the Src family of tyrosine kinases.

^ ^a ^b ^c ENSG00000285369 GRCh38: Ensembl release 89: ENSG00000136573, ENSG00000285369 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000014453 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Drebin JA, Hartzell SW, Griffin C, Campbell MJ, Niederhuber JE (Mar 1995). "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)". Oncogene. 10 (3): 477–86. PMID 7845672.
^ "Entrez Gene: BLK B lymphoid tyrosine kinase".

[refGRCh38Ensembl-1] ENSG00000285369 GRCh38: Ensembl release 89: ENSG00000136573, ENSG00000285369 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000014453 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7845672-5] Drebin JA, Hartzell SW, Griffin C, Campbell MJ, Niederhuber JE (Mar 1995). "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)". Oncogene. 10 (3): 477–86. PMID 7845672.

[entrez-6] "Entrez Gene: BLK B lymphoid tyrosine kinase".

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