Tyrosine-protein kinase SYK

SYK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A81, 1CSY, 1CSZ, 1XBA, 1XBB, 1XBC, 3BUW, 3EMG, 3FQE, 3FQH, 3FQS, 3SRV, 3TUB, 3TUC, 3TUD, 3VF8, 3VF9, 4DFL, 4DFN, 4F4P, 4FL1, 4FL2, 4FL3, 4FYN, 4FYO, 4FZ6, 4FZ7, 4GFG, 4I0R, 4I0S, 4I0T, 4PUZ, 4PV0, 4PX6, 4RX7, 4RX8, 4RX9, 5CXH, 5CXZ, 5CY3, 4XG6, 4XG2, 4XG3, 4XG8, 4XG7, 4YJR, 4YJP, 5C27, 4RSS, 4XG4, 5C26, 4YJV, 4YJO, 4WNM, 4YJT, 4YJU, 4YJS, 4XG9, 5GHV
Identifiers
Aliases	SYK, p72-Syk, spleen tyrosine kinase, spleen associated tyrosine kinase, IMD82
External IDs	OMIM: 600085; MGI: 99515; HomoloGene: 2390; GeneCards: SYK; OMA:SYK - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	90,898,549 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	52,802,828 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; epithelium of nasopharynx; ; bone marrow cells; ; appendix; ; trabecular bone; ; lymph node; ; spleen; ; jejunal mucosa;
	Top expressed in
	granulocyte; ; spleen; ; tibiofemoral joint; ; blood; ; mesenteric lymph nodes; ; stroma of bone marrow; ; Ileal epithelium; ; ankle joint; ; subcutaneous adipose tissue; ; lumbar subsegment of spinal cord;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	kinase activity; ATP binding; protein kinase activity; non-membrane spanning protein tyrosine kinase activity; protein serine/threonine kinase activity; transferase activity; integrin binding; protein binding; protein tyrosine kinase activity; protein kinase binding; nucleotide binding; phosphatase binding; Toll-like receptor binding; phosphotyrosine residue binding; SH2 domain binding; interleukin-15 receptor binding;
Cellular component	cytoplasm; cytosol; membrane; extrinsic component of cytoplasmic side of plasma membrane; nucleus; early phagosome; B cell receptor complex; plasma membrane; T cell receptor complex; protein-containing complex;
Biological process	leukocyte cell-cell adhesion; adaptive immune response; positive regulation of receptor internalization; neutrophil activation involved in immune response; platelet activation; Fc-epsilon receptor signaling pathway; protein phosphorylation; cell surface receptor signaling pathway; regulation of DNA-binding transcription factor activity; serotonin secretion; angiogenesis; animal organ morphogenesis; positive regulation of cell adhesion mediated by integrin; cell population proliferation; regulation of platelet aggregation; B cell receptor signaling pathway; positive regulation of calcium-mediated signaling; blood vessel morphogenesis; Fc-gamma receptor signaling pathway involved in phagocytosis; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of tumor necrosis factor-mediated signaling pathway; serotonin secretion by platelet; cellular response to low-density lipoprotein particle stimulus; stimulatory C-type lectin receptor signaling pathway; lymph vessel development; neutrophil chemotaxis; macrophage activation involved in immune response; defense response to bacterium; positive regulation of alpha-beta T cell proliferation; regulation of ERK1 and ERK2 cascade; positive regulation of peptidyl-tyrosine phosphorylation; protein autophosphorylation; leukotriene biosynthetic process; viral process; positive regulation of alpha-beta T cell differentiation; cellular response to molecule of fungal origin; regulation of neutrophil degranulation; phosphorylation; immune system process; positive regulation of B cell differentiation; beta selection; leukocyte activation involved in immune response; peptidyl-tyrosine autophosphorylation; integrin-mediated signaling pathway; regulation of superoxide anion generation; enzyme linked receptor protein signaling pathway; intracellular signal transduction; receptor internalization; positive regulation of bone resorption; positive regulation of mast cell degranulation; regulation of arachidonic acid secretion; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; regulation of phagocytosis; regulation of platelet activation; positive regulation of gamma-delta T cell differentiation; positive regulation of type I interferon production; inflammatory response; innate immune response; collagen-activated tyrosine kinase receptor signaling pathway; positive regulation of peptidyl-tyrosine autophosphorylation; protein import into nucleus; positive regulation of interleukin-4 production; interleukin-2-mediated signaling pathway; interleukin-3-mediated signaling pathway; positive regulation of cold-induced thermogenesis; positive regulation of protein-containing complex assembly; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	6850
	20963
	ENSG00000165025
	ENSMUSG00000021457
	P43405
	P48025
	NM_001135052; NM_001174167; NM_001174168; NM_003177
	NM_001198977; NM_011518
	NP_001128524; NP_001167638; NP_001167639; NP_003168
	NP_001185906; NP_035648
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165025 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021457 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SYK Spleen tyrosine kinase".
^ Chan AC, Iwashima M, Turck CW, Weiss A (November 1992). "ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain". Cell. 71 (4): 649–62. doi:10.1016/0092-8674(92)90598-7. PMID 1423621. S2CID 54326428.
^ Ku G, Malissen B, Mattei MG (1994). "Chromosomal location of the Syk and ZAP-70 tyrosine kinase genes in mice and humans". Immunogenetics. 40 (4): 300–2. doi:10.1007/BF00189976. PMID 8082894. S2CID 33774157.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165025 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021457 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SYK Spleen tyrosine kinase".

[pmid1423621-6] Chan AC, Iwashima M, Turck CW, Weiss A (November 1992). "ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain". Cell. 71 (4): 649–62. doi:10.1016/0092-8674(92)90598-7. PMID 1423621. S2CID 54326428.

[pmid8082894-7] Ku G, Malissen B, Mattei MG (1994). "Chromosomal location of the Syk and ZAP-70 tyrosine kinase genes in mice and humans". Immunogenetics. 40 (4): 300–2. doi:10.1007/BF00189976. PMID 8082894. S2CID 33774157.

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