Tyrosine kinase 2

TYK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LXN, 3LXP, 3NYX, 3NZ0, 3ZON, 4GFO, 4GIH, 4GII, 4GJ2, 4GJ3, 4GVJ, 4OLI, 4PO6, 4PY1, 4WOV, 5C01, 5C03, 5F20, 5F1Z
Identifiers
Aliases	TYK2, IMD35, JTK1, tyrosine kinase 2, Non-receptor tyrosine-protein kinase
External IDs	OMIM: 176941; MGI: 1929470; HomoloGene: 20712; GeneCards: TYK2; OMA:TYK2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 10,350,529 bp[1] End 10,380,572 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A3 Start 21,015,364 bp[2] End 21,042,539 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte right hemisphere of cerebellum anterior pituitary right lobe of thyroid gland spleen right uterine tube right lobe of liver tibial nerve right ovary apex of heart Top expressed in granulocyte mesenteric lymph nodes tibiofemoral joint spermatocyte blood renal corpuscle Rostral migratory stream spleen lip bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity type 1 angiotensin receptor binding growth hormone receptor binding kinase activity protein binding protein tyrosine kinase activity ATP binding non-membrane spanning protein tyrosine kinase activity Cellular component cytoplasm cytosol membrane extrinsic component of cytoplasmic side of plasma membrane extracellular exosome cytoskeleton nucleus Biological process cell differentiation intracellular signal transduction phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway protein phosphorylation regulation of type I interferon-mediated signaling pathway regulation of cell population proliferation type I interferon signaling pathway peptidyl-tyrosine autophosphorylation innate immune response cell migration interleukin-12-mediated signaling pathway peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway interleukin-23-mediated signaling pathway interleukin-27-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7297 54721 Ensembl ENSG00000105397 ENSMUSG00000032175 UniProt P29597 Q9R117 RefSeq (mRNA) NM_003331 NM_001205312 NM_018793 RefSeq (protein) NP_003322 NP_001192241 NP_061263 Location (UCSC) Chr 19: 10.35 – 10.38 Mb Chr 9: 21.02 – 21.04 Mb PubMed search [3] [4]
Wikidata
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Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene.^[5][6]

TYK2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3).^[7] It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling.