U.S. Route 221

U.S. Route 221 marker
U.S. Route 221
Map
US 221 highlighted in red
Route information
Auxiliary route of US 21
Length734 mi[citation needed] (1,181 km)
Existed1930[citation needed]–present
Major junctions
South end
Major intersections
North end
Location
CountryUnited States
StatesFlorida, Georgia, South Carolina, North Carolina, Virginia
Highway system

U.S. Route 221 (US 221) is a 734-mile-long (1,181 km) spur of U.S. Route 21. It travels from Perry, Florida, at US 19/US 98/US 27 Alternate to Lynchburg, Virginia, at US 29 Business (Lynchburg Expressway). It travels through the states of Florida, Georgia, South Carolina, North Carolina, and Virginia. It travels through the cities of Valdosta, Georgia; Spartanburg, South Carolina; Marion, North Carolina; Roanoke, Virginia; and Lynchburg, Virginia.