U.S. Route 385 in Colorado

U.S. Highway 385
High Plains Highway
US 385 highlighted in red
Route information
Maintained by CDOT
Length	318.52 mi[1] (512.61 km)
Existed	1958 (1958)–present
Major junctions
South end	US 287 / US 385 / SH-3 towards Boise City, OK
Major intersections	US 50 / US 287 in Lamar US 50 / US 400 in Granada US 40 in Cheyenne Wells I-70 in Burlington US 34 in Wray I-76 in Julesburg
North end	US 385 towards Chappell, NE
Location
Country	United States
State	Colorado
Counties	Baca, Prowers, Kiowa, Cheyenne, Kit Carson, Yuma, Phillips, Sedgwick
Highway system
United States Numbered Highway System List Special Divided Colorado State Highway System Interstate US State Scenic
← SH 371 → SH 389

U.S. Highway 385 (US 385), also known as the High Plains Highway north of Cheyenne Wells, is the easternmost significant north–south state highway in the U.S. state of Colorado, and many of the state's major east–west routes intersect with US 385 before crossing into neighboring Kansas and Nebraska. It enters the state from Oklahoma while overlapped with US 287, but splits at Lamar to follow its own route through the Eastern Plains to Nebraska.