U.S. Route 421

U.S. Route 421
US 421 highlighted in red
Route information
Auxiliary route of US 21
Length	941 mi (1,514 km)
Existed	1930–present
Major junctions
South end	NC 211 / Fort Fisher-Southport Ferry at Fort Fisher, NC
Major intersections	I-95 in Dunn, NC I-85 in Greensboro, NC I-40 in Greensboro and Winston-Salem, NC I-77 near Yadkinville, NC I-81 near Bristol, VA I-75 near Lexington, KY I-69 / I-74 / I-465 in Indianapolis, IN I-70 in Indianapolis, IN I-80 / I-90 near Otis, IN I-94 near Michigan City, IN
North end	US 20 at Michigan City, IN
Location
Country	United States
States	North Carolina, Tennessee, Virginia, Kentucky, Indiana
Highway system
United States Numbered Highway System List Special Divided

U.S. Route 421 (also U.S. Highway 421, US 421) is a diagonal northwest–southeast United States Numbered Highway in the states of North Carolina, Tennessee, Virginia, Kentucky, and Indiana. The highway runs for 941 miles (1,514 km) from Fort Fisher, North Carolina, to US 20 in Michigan City, Indiana. Along its routing, US 421 serves several cities including Wilmington, North Carolina; Greensboro, North Carolina; Bristol, Tennessee and Virginia; Lexington, Kentucky; and Indianapolis, Indiana. US 421 is a spur route of US 21, which it meets west of Yadkinville, North Carolina.