U.S. Route 421 in Indiana

U.S. Route 421
US 421 highlighted in red
Route information
Maintained by INDOT
Length	255.065 mi[1] (410.487 km)
Existed	1951–present
Major junctions
South end	US 421 near Madison
Major intersections	US 50 in Versailles I-74 in Greensburg I-69 / I-74 / I-465 in Indianapolis I-70 in Indianapolis I-69 in Indianapolis US 24 in Monticello US 30 in Wanatah US 6 in Westville I-80 / I-90 / Indiana Toll Road near Otis I-94 near Michigan City
North end	US 20 in Michigan City
Location
Country	United States
State	Indiana
Counties	Jefferson, Ripley, Decatur, Rush, Shelby, Marion, Hamilton, Boone, Clinton, Carroll, White, Pulaski, Starke, LaPorte
Highway system
United States Numbered Highway System List Special Divided Indiana State Highway System Interstate US State Scenic
← SR 364 → SR 427

U.S. Route 421 (US 421) enters Indiana from Kentucky, proceeding northwest to Indianapolis, joining Interstate 465, and then continuing northwest to Michigan City.

US 421 winds through the southern part of Indiana as it runs from Madison, in the southeastern part of the state, to Indianapolis (the capital). North of Greensburg, US 421 intersects and merges with I-74 west, through the Shelbyville area en route to Indianapolis. Originally, US 421 followed Michigan Road into Indianapolis, which turns into Southeastern Avenue and heads to downtown. US 421 then merged with US 40 (Washington St.) and headed to West Street, then turned north, following West Street, Northwestern Avenue (later Martin Luther King Jr. Street), and Michigan Road up to the northwest side of the city. US 421 passed an Indianapolis landmark, the Pyramids. North of Indianapolis, US 421 continues to the north-northwest, providing a direct highway link between Indianapolis and Michigan City. US 421 ends at its junction with US 20 on the south side of Michigan City. Originally, the highway's end was a few miles north at the junction with US 12 near the shores of Lake Michigan.