U.S. Route 45 Alternate

U.S. Highway 45 Alternate
Route information
Maintained by MDOT
Length	62.9 mi[1] (101.2 km)
Existed	1968–present
Major junctions
South end	US 45 in Brooksville
Major intersections	US 82 / MS 12 / MS 25 in Mayhew MS 50 in West Point MS 8 near Gibson MS 41 near Okolona
North end	US 45 / US 278 / MS 145 in Shannon
Location
Country	United States
State	Mississippi
Counties	Noxubee, Lowndes, Clay, Monroe, Chickasaw, Lee
Highway system
United States Numbered Highway System List Special Divided Mississippi State Highway System Interstate US State
← US 45 → MS 46

U.S. Route 45 Alternate (US 45 Alternate, also signed as US 45A) is a 62.9-mile-long (101.2 km) alternate route of US 45 in northeastern Mississippi, running from Brooksville, through West Point, to Shannon, which lies just south of Tupelo. Excluding the route through West Point, the entire length of US 45 Alternate is a four-lane divided expressway, with interchanges at most major junctions.

It is the one of only two signed special route of any U.S. Highway within the entire state of Mississippi, with the rest being signed as normal state highways.