U.S. Route 48 is part of the Appalachian Development Highway System.
U.S. Route 48 may also refer to:
- U.S. Route 48 (1926), a highway in California and one of the original routes in the United States Numbered Highways system
- U.S. Route 48 (1969–1989), a highway in West Virginia and Maryland now designated as Interstate 68
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This disambiguation page lists articles about roads and streets with the same name.
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