U.S. Route 49

U.S. Route 49 marker
U.S. Route 49
Map
US 49 highlighted in red
Route information
Length516 mi[citation needed] (830 km)
Existed1926[citation needed]–present
Southern section
South end US 90 at Gulfport, MS
Major intersections
North end US 49E / US 49W at Yazoo City, MS
Northern section
South end US 49E / US 49W at Tutwiler, MS
Major intersections
North end US 62 / AR 1 / AR 139 at Piggott, AR
Location
CountryUnited States
StatesMississippi, Arkansas
Highway system
US 48US US 50
MS 48MS US 49E
I-49AR AR 50

U.S. Route 49 (US 49) is a north–south United States highway. The highway's northern terminus is in Piggott, Arkansas, at an intersection with US Route 62/Highway 1/Highway 139 (US 62/AR 1/AR 139). Its southern terminus is in Gulfport, Mississippi, at an intersection with U.S. Route 90. US 49 is approximately 516 miles (830 km) in length.

It was at the junction of US 49 and U.S. Route 61 that blues singer Robert Johnson is said to have sold his soul to the Devil. The highway is also the subject of songs by Big Joe Williams and Howlin' Wolf (Chester Arthur Burnett).