U.S. Route 52 in Ohio

U.S. Route 52
US 52 highlighted in red
Route information
Maintained by ODOT
Length	180.968 mi[1] (291.240 km)
Tourist routes	Ohio River Scenic Byway
Major junctions
West end	US 52 / I-74 at the Indiana state line near Harrison
Major intersections	I-275 near Blue Jay US 27 in Cincinnati I-75 in Cincinnati US 127 in Cincinnati US 42 in Cincinnati US 22 / SR 3 in Cincinnati I-275 / Kellogg Road in Cincinnati US 62 / US 68 in Ripley US 23 in Portsmouth
East end	US 52 at the West Virginia state line near Huntington, WV
Location
Country	United States
State	Ohio
Counties	Hamilton, Clermont, Brown, Adams, Scioto, Lawrence
Highway system
United States Numbered Highway System List Special Divided Ohio State Highway System Interstate US State Scenic
← SR 51 → SR 53

U.S. Route 52 (US 52) runs east–west across the southern part of the state of Ohio along the Ohio River, passing through or very near the cities and towns of Cincinnati, Portsmouth, and Ironton. For its first 19 miles (31 km) or so, the highway runs concurrently with Interstate 74 (I-74) and I-75 before it winds through downtown Cincinnati for several miles. The route is primarily two lanes between New Richmond and West Portsmouth, Ohio, where it becomes a four-lane partial access highway until it exits the state near Chesapeake.