U.S. Route 52 in South Carolina

U.S. Highway 52
US 52 highlighted in red
Route information
Maintained by SCDOT
Length	159.960 mi[1][2][3][4][5][6] (257.431 km)
Existed	1935[citation needed]–present
Major junctions
East end	Line Street / Meeting Street in Charleston
Major intersections	I-26 / US 17 in Charleston US 78 in North Charleston I-526 in North Charleston US 17 Alt. in Moncks Corner US 521 near Greeleyville US 378 in Lake City US 301 / SC 327 in Effingham US 76 in Florence I-95 in Florence US 1 / SC 9 in Cheraw
West end	US 52 at the North Carolina line near Cheraw
Location
Country	United States
State	South Carolina
Counties	Charleston, Berkeley, Williamsburg, Florence, Darlington, Chesterfield
Highway system
United States Numbered Highway System List Special Divided South Carolina State Highway System Interstate US State Scenic
← SC 51 → SC 53

U.S. Route 52 (US 52) is an east–west United States Numbered Highway that runs for 159.960-mile (257.431 km) from Charleston to the North Carolina state line near Cheraw. It serves as a strategic highway through the central part of the state.