U.S. Route 78

U.S. Route 78
U.S. Route 78
	US 78 highlighted in red
Route information
Length	843.3 mi[citation needed] (1,357.2 km)
Existed	1926[citation needed]–present
Major junctions
West end	I-57 / US 67 / AR 226 near Cash, AR
	I-55 at Blytheville, AR; I-40 at West Memphis, AR; I-69 at Memphis, TN; I-22 from Byhalia, MS to Graysville, AL; I-20 four times in Alabama; I-59 at Birmingham, AL; I-65 at Birmingham, AL; I-75 / I-85 at Atlanta, GA; I-95 at St. George, SC; I-26 at North Charleston, SC;
East end	Line Street at Charleston, SC
Location
Country	United States
States	Arkansas, Tennessee, Mississippi, Alabama, Georgia, South Carolina
Highway system
	United States Numbered Highway System; List; Special; Divided;
	Arkansas Highway System; Interstate; US; State; Business; Spurs; Suffixed; Scenic; Heritage;
	Tennessee State Routes; Interstate; US; State;
	Mississippi State Highway System; Interstate; US; State;

U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 843.3 miles (1,357.2 km) from Cash, Arkansas, to Charleston, South Carolina. From Byhalia, Mississippi to Birmingham, Alabama, US 78 runs concurrently with Interstate 22 (I-22). The highway’s western terminus is at I-57/US 67 near Cash, and its eastern terminus is on Line Street, in Charleston. Prior to November 2023, before the western extension, the highway's former western terminus was at US 64/US 70/US 79 (Second Street) in Memphis, Tennessee.