U2 small nuclear RNA auxiliary factor 1

U2AF1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1JMT
Identifiers
Aliases	U2AF1, FP793, RN, RNU2AF35, U2AFBP, U2 small nuclear RNA auxiliary factor 1
External IDs	OMIM: 191317; HomoloGene: 134334; GeneCards: U2AF1; OMA:U2AF1 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	43,107,570 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; left uterine tube; ; bone marrow; ; olfactory zone of nasal mucosa; ; mucosa of transverse colon; ; appendix; ; stromal cell of endometrium; ; right lung; ; monocyte; ; granulocyte;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein binding; nucleic acid binding; pre-mRNA 3'-splice site binding; RNA binding; RS domain binding;
Cellular component	Cajal body; nuclear speck; catalytic step 2 spliceosome; U2AF complex; nucleoplasm; spliceosomal complex; nucleus;
Biological process	termination of RNA polymerase II transcription; positive regulation of protein targeting to mitochondrion; mRNA processing; mRNA export from nucleus; regulation of autophagy of mitochondrion; RNA splicing; mRNA 3'-end processing; RNA export from nucleus; mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	7307
	n/a
	ENSG00000160201
	n/a
	Q01081; P0DN76
	n/a
	NM_001025203; NM_001025204; NM_006758
	n/a
NP_001307575; NP_001307577; NP_001307579; NP_001307580; NP_001020374;
	NP_001020375; NP_006749; NP_001020374; NP_001020375; NP_006749
	n/a
	Wikidata
View/Edit Human

Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.^[3]^[4]^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160201 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lalioti MD, Gos A, Green MR, Rossier C, Morris MA, Antonarakis SE (January 1997). "The gene for human U2 snRNP auxiliary factor small 35-kDa subunit (U2AF1) maps to the progressive myoclonus epilepsy (EPM1) critical region on chromosome 21q22.3". Genomics. 33 (2): 298–300. doi:10.1006/geno.1996.0196. PMID 8660980.
^ Kalcheva I, Plass C, Sait S, Eddy R, Shows T, Watkins-Chow D, Camper S, Shibata H, Ueda T, Takagi N (Dec 1994). "Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5". Cytogenet Cell Genet. 68 (1–2): 19–24. doi:10.1159/000133881. PMID 7956352.
^ "Entrez Gene: U2AF1 U2 small nuclear RNA auxiliary factor 1".