| U7 small nuclear RNA | |
|---|---|
 Predicted secondary structure and sequence conservation of U7 | |
| Identifiers | |
| Symbol | U7 |
| Rfam | RF00066 |
| Other data | |
| RNA type | Gene; snRNA |
| Domain(s) | Eukaryota |
| SO | SO:0000274 |
| PDB structures | PDBe |
The U7 small nuclear RNA (U7 snRNA) is an RNA molecule and a component of the small nuclear ribonucleoprotein complex (U7 snRNP). The U7 snRNA is required for histone pre-mRNA processing.
The 5' end of the U7 snRNA binds the HDE (histone downstream element), a conserved purine-rich region, located 15 nucleotides downstream the histone mRNA cleavage site.[1][2] The binding of the HDE region by the U7 snRNA, through complementary base-pairing, is an important step for the future recruitment of cleavage factors during histone pre-mRNA processing.[3]
- ^ Spycher C, Streit A, Stefanovic B, Albrecht D, Koning TH, Schümperli D (1994). "3' end processing of mouse histone pre-mRNA: evidence for additional base-pairing between U7 snRNA and pre-mRNA". Nucleic Acids Res. 22 (20): 4023–4030. doi:10.1093/nar/22.20.4023. PMC 331885. PMID 7937126.
- ^ Mowry KL, Steitz JA (1987). "Identification of the human U7 snRNP as one of several factors involved in the 3' end maturation of histone premessenger RNA's". Science. 238 (4834): 1682–1687. Bibcode:1987Sci...238.1682M. doi:10.1126/science.2825355. PMID 2825355.
- ^ Marzluff, William F.; Wagner, Eric J.; Duronio, Robert J. (2008). "Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail". Nature Reviews Genetics. 9 (11): 843–854. doi:10.1038/nrg2438. PMC 2715827. PMID 18927579.