UDP glucuronosyltransferase 1 family, polypeptide A1

UGT1A1
Identifiers
Aliases	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A, UDP glucuronosyltransferase family 1 member A1
External IDs	OMIM: 191740; MGI: 98898; HomoloGene: 128034; GeneCards: UGT1A1; OMA:UGT1A1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	233,773,300 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	88,146,719 bp
RNA expression pattern
	Top expressed in
	duodenum; ; right lobe of liver; ; testicle; ; mucosa of transverse colon; ; human kidney; ; rectum; ; urinary bladder; ; renal cortex; ; gallbladder; ; olfactory zone of nasal mucosa;
	Top expressed in
	duodenum; ; jejunum; ; ileum; ; lip; ; colon; ; hepatobiliary system; ; liver; ; vasculature of organ; ; zone of skin; ; ventricular system;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; enzyme inhibitor activity; retinoic acid binding; hexosyltransferase activity; protein homodimerization activity; glycosyltransferase activity; steroid binding; protein heterodimerization activity; enzyme binding; glucuronosyltransferase activity; UDP-glycosyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; integral component of plasma membrane; cytochrome complex; endoplasmic reticulum chaperone complex; endoplasmic reticulum;
Biological process	steroid metabolic process; response to organic cyclic compound; cellular response to ethanol; estrogen metabolic process; response to nutrient; negative regulation of steroid metabolic process; bilirubin conjugation; response to steroid hormone; response to glucocorticoid; retinoic acid metabolic process; negative regulation of cellular glucuronidation; response to organic substance; response to lipopolysaccharide; cellular response to hormone stimulus; heme catabolic process; cellular response to glucocorticoid stimulus; acute-phase response; heterocycle metabolic process; animal organ regeneration; response to starvation; flavone metabolic process; liver development; metabolism; negative regulation of glucuronosyltransferase activity; response to ethanol; negative regulation of fatty acid metabolic process; biphenyl catabolic process; cellular response to estradiol stimulus; flavonoid glucuronidation; cellular glucuronidation; xenobiotic glucuronidation; cellular response to xenobiotic stimulus; negative regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologs
	54658
	394436
	ENSG00000241635
	ENSMUSG00000089960
	P22309
	Q63886
	NM_000463
	NM_201645
	NP_000454
	NP_964007
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucuronosyltransferase 1-1 also known as UGT-1A is an enzyme that in humans is encoded by the UGT1A1 gene.^[5]^[6]

UGT-1A is a uridine diphosphate glucuronosyltransferase (UDP-glucuronosyltransferase, UDPGT), an enzyme of the glucuronidation pathway that transforms small lipophilic (fat-soluble) molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000241635 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000089960 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (August 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054.
^ Strassburg CP, Manns MP, Tukey RH (April 1998). "Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8". J. Biol. Chem. 273 (15): 8719–26. doi:10.1074/jbc.273.15.8719. PMID 9535849.
^ "Entrez Gene: UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000241635 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000089960 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9295054-5] Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (August 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054.

[pmid9535849-6] Strassburg CP, Manns MP, Tukey RH (April 1998). "Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8". J. Biol. Chem. 273 (15): 8719–26. doi:10.1074/jbc.273.15.8719. PMID 9535849.

[nlm54658-7] "Entrez Gene: UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1".

[1]

[2]

[3]

[4]

[5]

[6]

[7]