UGT2B10

UGT2B10
Identifiers
Aliases	UGT2B10, UDPGT2B10, UDP glucuronosyltransferase family 2 member B10
External IDs	OMIM: 600070; MGI: 2140962; HomoloGene: 117389; GeneCards: UGT2B10; OMA:UGT2B10 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	68,832,023 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	87,054,796 bp
RNA expression pattern
	Top expressed in
	liver; ; right lobe of liver; ; testicle; ; gallbladder; ; rectum; ; mucosa of transverse colon; ; islet of Langerhans; ; kidney; ; renal cortex; ; left testis;
	Top expressed in
	left lobe of liver; ; pyloric antrum; ; mucous cell of stomach; ; left colon; ; jejunum; ; duodenum; ; migratory enteric neural crest cell; ; epithelium of stomach; ; ileum; ; gallbladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glycosyltransferase activity; transferase activity; hexosyltransferase activity; glucuronosyltransferase activity; UDP-glycosyltransferase activity;
Cellular component	integral component of membrane; organelle membrane; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; endoplasmic reticulum; membrane;
Biological process	metabolism; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
	7365
	100727
	ENSG00000275190; ENSG00000109181
	ENSMUSG00000029260
	P36537
	n/a
	NM_001290091; NM_001075; NM_001144767
	NM_153598
	NP_001066; NP_001138239; NP_001277020
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucuronosyltransferase 2B10 is an enzyme that in humans is encoded by the UGT2B10 gene.^[5]^[6] It is responsible for glucuronidation of nicotine and cotinine.^[7]^[8]

^ ^a ^b ^c ENSG00000109181 GRCh38: Ensembl release 89: ENSG00000275190, ENSG00000109181 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029260 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI (July 1993). "cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily". Biochemical and Biophysical Research Communications. 194 (1): 496–503. doi:10.1006/bbrc.1993.1847. PMID 8333863.
^ "Entrez Gene: UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10".
^ Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P (October 2010). "Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms". Cancer Research. 70 (19): 7543–52. doi:10.1158/0008-5472.CAN-09-4582. PMC 2998997. PMID 20876810.
^ Wassenaar CA, Conti DV, Das S, Chen P, Cook EH, Ratain MJ, et al. (January 2015). "UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers". Cancer Epidemiology, Biomarkers & Prevention. 24 (1): 94–104. doi:10.1158/1055-9965.EPI-14-0804. PMC 4294984. PMID 25277794.

[refGRCh38Ensembl-1] ENSG00000109181 GRCh38: Ensembl release 89: ENSG00000275190, ENSG00000109181 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029260 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8333863-5] Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI (July 1993). "cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily". Biochemical and Biophysical Research Communications. 194 (1): 496–503. doi:10.1006/bbrc.1993.1847. PMID 8333863.

[entrez-6] "Entrez Gene: UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10".

[pmid20876810-7] Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P (October 2010). "Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms". Cancer Research. 70 (19): 7543–52. doi:10.1158/0008-5472.CAN-09-4582. PMC 2998997. PMID 20876810.

[pmid25277794-8] Wassenaar CA, Conti DV, Das S, Chen P, Cook EH, Ratain MJ, et al. (January 2015). "UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers". Cancer Epidemiology, Biomarkers & Prevention. 24 (1): 94–104. doi:10.1158/1055-9965.EPI-14-0804. PMC 4294984. PMID 25277794.

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