UGT2B15

UGT2B15
Identifiers
Aliases	UGT2B15, HLUG4, UDPGT 2B8, UDPGT2B15, UDPGTH3, UGT2B8, UDP glucuronosyltransferase family 2 member B15
External IDs	OMIM: 600069; MGI: 1919023; HomoloGene: 133957; GeneCards: UGT2B15; OMA:UGT2B15 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	68,670,652 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	87,074,389 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; liver; ; right lobe of liver; ; gonad; ; islet of Langerhans; ; duodenum; ; mucosa of transverse colon; ; body of pancreas; ; body of stomach; ; rectum;
	Top expressed in
	left lobe of liver; ; embryo; ; lumbar subsegment of spinal cord; ; right ventricle; ; tibiofemoral joint; ; sexually immature organism; ; medial head of gastrocnemius muscle; ; lumbar spinal ganglion; ; stria vascularis; ; carotid body;
	More reference expression data
	n/a
Gene ontology
Molecular function	hexosyltransferase activity; glucuronosyltransferase activity; glycosyltransferase activity; transferase activity; retinoic acid binding; UDP-glycosyltransferase activity;
Cellular component	endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; integral component of membrane; organelle membrane; endoplasmic reticulum;
Biological process	steroid metabolic process; cellular glucuronidation; metabolism; xenobiotic metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	7366
	71773
	ENSG00000277132; ENSG00000196620
	ENSMUSG00000035836
	P54855
	Q8R084
	NM_001076
	NM_152811
	NP_001067
	NP_690024
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucuronosyltransferase 2B15 is an enzyme that in humans is encoded by the UGT2B15 gene.^[5]^[6]

The UGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B8 demonstrates reactivity with estriol. See UGT2B4 (MIM 600067).[supplied by OMIM]^[6]

^ ^a ^b ^c ENSG00000196620 GRCh38: Ensembl release 89: ENSG00000277132, ENSG00000196620 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035836 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Monaghan G, Clarke DJ, Povey S, See CG, Boxer M, Burchell B (Feb 1995). "Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13". Genomics. 23 (2): 496–9. doi:10.1006/geno.1994.1531. PMID 7835904.
^ ^a ^b "Entrez Gene: UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15".

[refGRCh38Ensembl-1] ENSG00000196620 GRCh38: Ensembl release 89: ENSG00000277132, ENSG00000196620 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035836 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7835904-5] Monaghan G, Clarke DJ, Povey S, See CG, Boxer M, Burchell B (Feb 1995). "Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13". Genomics. 23 (2): 496–9. doi:10.1006/geno.1994.1531. PMID 7835904.

[entrez-6] "Entrez Gene: UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15".

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