UQCRC2

UQCRC2
Identifiers
Aliases	UQCRC2, MC3DN5, QCR2, UQCR2, ubiquinol-cytochrome c reductase core protein II, ubiquinol-cytochrome c reductase core protein 2
External IDs	OMIM: 191329; MGI: 1914253; HomoloGene: 37764; GeneCards: UQCRC2; OMA:UQCRC2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	21,983,660 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	120,258,747 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; body of tongue; ; Skeletal muscle tissue of rectus abdominis; ; jejunal mucosa; ; apex of heart; ; duodenum; ; mucosa of sigmoid colon; ; rectum; ; muscle of thigh; ; biceps brachii;
	Top expressed in
	Paneth cell; ; myocardium of ventricle; ; medullary collecting duct; ; facial motor nucleus; ; substantia nigra; ; cardiac muscles; ; atrioventricular junction; ; cardiac muscle tissue of left ventricle; ; migratory enteric neural crest cell; ; atrioventricular valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; zinc ion binding; metal ion binding; protein binding; catalytic activity; metalloendopeptidase activity; endopeptidase activity;
Cellular component	membrane; myelin sheath; nucleoplasm; mitochondrion; respirasome; extracellular exosome; mitochondrial inner membrane; mitochondrial respiratory chain complex III; mitochondrial respiratory chain complex IV; mitochondrial processing peptidase complex;
Biological process	proteolysis; aerobic respiration; oxidative phosphorylation; mitochondrial electron transport, ubiquinol to cytochrome c; protein processing involved in protein targeting to mitochondrion;
	Sources:Amigo / QuickGO
Orthologs
	7385
	67003
	ENSG00000140740
	ENSMUSG00000030884
	P22695
	Q9DB77
	NM_003366
	NM_025899
	NP_003357
	NP_080175
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2), also known as QCR2, UQCR2, or MC3DN5 is a protein that in humans is encoded by the UQCRC2 gene.^[5] The product of UQCRC2 is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and "Rieske-associated protein."^[6]^[7] Defects in UQCRC2 are associated with mitochondrial complex III deficiency, nuclear, type 5.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140740 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030884 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: UQCRC2 ubiquinol-cytochrome c reductase core protein II".
^ Duncan AM, Ozawa T, Suzuki H, Rozen R (November 1993). "Assignment of the gene for the core protein II (UQCRC2) subunit of the mitochondrial cytochrome bc1 complex to human chromosome 16p12". Genomics. 18 (2): 455–6. doi:10.1006/geno.1993.1500. PMID 8288258.
^ Hosokawa Y, Suzuki H, Toda H, Nishikimi M, Ozawa T (August 1989). "Complementary DNA encoding core protein II of human mitochondrial cytochrome bc1 complex. Substantial diversity in deduced primary structure from its yeast counterpart". The Journal of Biological Chemistry. 264 (23): 13483–8. doi:10.1016/S0021-9258(18)80022-9. PMID 2547763.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140740 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030884 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: UQCRC2 ubiquinol-cytochrome c reductase core protein II".

[pmid8288258-6] Duncan AM, Ozawa T, Suzuki H, Rozen R (November 1993). "Assignment of the gene for the core protein II (UQCRC2) subunit of the mitochondrial cytochrome bc1 complex to human chromosome 16p12". Genomics. 18 (2): 455–6. doi:10.1006/geno.1993.1500. PMID 8288258.

[pmid2547763-7] Hosokawa Y, Suzuki H, Toda H, Nishikimi M, Ozawa T (August 1989). "Complementary DNA encoding core protein II of human mitochondrial cytochrome bc1 complex. Substantial diversity in deduced primary structure from its yeast counterpart". The Journal of Biological Chemistry. 264 (23): 13483–8. doi:10.1016/S0021-9258(18)80022-9. PMID 2547763.

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