UQCRFS1

UQCRFS1
Identifiers
Aliases	UQCRFS1, RIP1, RIS1, RISP, UQCR5, ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1, MC3DN10
External IDs	OMIM: 191327; MGI: 1913944; HomoloGene: 4378; GeneCards: UQCRFS1; OMA:UQCRFS1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	29,213,151 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	30,729,345 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; left ventricle; ; mucosa of transverse colon; ; muscle of thigh; ; apex of heart; ; right auricle; ; skeletal muscle tissue; ; right adrenal gland; ; right adrenal cortex; ; rectum;
	Top expressed in
	myocardium of ventricle; ; right ventricle; ; soleus muscle; ; extraocular muscle; ; digastric muscle; ; vastus lateralis muscle; ; thoracic diaphragm; ; temporal muscle; ; right kidney; ; triceps brachii muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquinol-cytochrome-c reductase activity; protein-containing complex binding; iron-sulfur cluster binding; metal ion binding; oxidoreductase activity; 2 iron, 2 sulfur cluster binding; oxidoreductase activity, acting on diphenols and related substances as donors; protein binding;
Cellular component	integral component of membrane; membrane; mitochondrial membranes; myelin sheath; mitochondrion; mitochondrial inner membrane; respirasome; mitochondrial respiratory chain complex III; mitochondrial respiratory chain complex IV;
Biological process	proton transmembrane transport; response to antibiotic; response to hormone; mitochondrial electron transport, ubiquinol to cytochrome c;
	Sources:Amigo / QuickGO
Orthologs
	7386
	66694
	ENSG00000169021
	ENSMUSG00000038462
	P47985
	Q9CR68
	NM_006003
	NM_025710
	NP_005994
	NP_079986
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1, also known as UQCRFS1, Rieske iron-sulfur (Fe-S) protein, Cytochrome b-c1 complex subunit 5, or Complex III subunit 5 is a protein which in humans is encoded by the UQCRFS1 gene.^[5] UQCRFS1 is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of both the product of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and the products of ten nuclear genes UQCRC1, UQCRC2, Cytochrome C1, UQCRFS1 (this protein, a type of Rieske protein), UQCRB,UQCRQ ("11kDa protein"), UQCRH (cyt c1 Hinge protein), UCRC ("cyt. c1 associated protein"), and UQCR ("Rieske-associated protein").^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169021 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038462 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1". This article incorporates text from this source, which is in the public domain.
^ Cite error: The named reference Uniprot was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169021 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038462 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1". This article incorporates text from this source, which is in the public domain.

[Uniprot-6] Cite error: The named reference Uniprot was invoked but never defined (see the help page).

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