Experiment was built in 1799 at Baltimore, Maryland; and first put to sea late in November 1799, Lieutenant William Maley in command.
Experiment joined the squadron commanded by Captain Silas Talbot on the Santo Domingo station, and for seven months, cruised against French privateers in the Caribbean, taking a number of valuable prizes. Action of 1 January 1800:On 1 January 1800, while becalmed in the Bight of Leogane with a convoy of four merchantmen, they were attacked by 11 armed pirate barges, flying French flags, manned by about four or five hundred buccaneers. In the seven hours of fighting that followed, the pirates boarded one of the merchantmen, killing her captain, and towed off two other ships of the convoy after their crews had abandoned them. But Experiment sank two of the attacking craft, and killed and wounded many of the pirates, suffering only one man wounded.[2] On 12 January captured schooner "Anne' (or Anna).[3] She was sent to Philadelphia where the ship was released by the Court in July.[4] On 2 February she captured a sloop.[5] On 4 February she captured schooner "Amphitheater".[6] "Ampitheatre" was made an armed tender for USS Constitution at the end of February, 1800.[7] She also took on the 4th a Danish flagged schooner loaded with André Rigaud's troops and ammo. Also captured one of André Rigaud's privateers, a sloop. The sloop and troops were disarmed, the ship ransomed and sent to shore with the prisoners.[8] Also on the 4th about 11 PM she had a brief engagement with an unknown vessel that escaped due to low manning from having so many prizes captured.[9] On 14 February she captured Spanish brigantine "Los Amigos", she was sent to Philadelphia where charges were dropped by the Court in September.[10] On 18 February, 1800 she captured French armed schooner L'Legere.[11] On 29 March she captured Spanish brig "St. Michael".[12] On 8 April she captured Spanish schooner "El Carmine" for not having papers.[13] On 15 May she captured schooner Mercator.[14] On 25 June she captured American slave sloop "Betsy" off Cuba.[15]
Arriving in the Delaware River early in July 1800, Experiment refitted, and returned to the West Indies under new commander, Lieutenant Charles Stewart Jr, Lt. Maley having been dismissed from the Service.[16] On 1 September she captured privateer schooner "Les Deux Amis".[17]. On 1 October she captured French Navy schooner "La Diana" with General André Rigaud on board.[18] Again successful in her patrols against the French, she captured several armed vessels. On 16 November she fought a four hour battle with an unknown vessel, after they struck it was discovered to be the British schooner "Louisa Bridges". The only casualty of the battle was Experiment's Boatswain was killed.[19] On 14 December she recaptured brig "Zebra", captured the day before by privateer schooner "La Flambeau".[20] On 26 December recaptured brig "Dove", and sloop "Lucy", both captured by privateer schooner "Patriot".[21] She also recaptured a number of American merchantmen, and 0n 19 January 1801 rescued 60 women and children and 7 crewmen, Spaniards, from the ship Eliza, wrecked on a reef off the island of Saona.[22]
Experiment returned to Norfolk early on, or just before, 4 February 1801.[23] In a letter dated 20 February to Josiah Parker, chairman of the Committee on Naval Affairs, Navy Secretary Stoddert recommended selling her.[24] She was laid up there until August, when she sailed to Baltimore. She was sold there in October, 1801 for $7,350.[25]