UXS1

UXS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B69, 4GLL, 4LK3, 4M55
Identifiers
Aliases	UXS1, SDR6E1, UGD, UDP-glucuronate decarboxylase 1
External IDs	OMIM: 609749; MGI: 1915133; HomoloGene: 41609; GeneCards: UXS1; OMA:UXS1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	106,194,301 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	43,827,800 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; renal medulla; ; cartilage tissue; ; tibia; ; visceral pleura; ; decidua; ; germinal epithelium; ; spinal ganglia; ; trigeminal ganglion; ; stromal cell of endometrium;
	Top expressed in
	decidua; ; motor neuron; ; Epithelium of choroid plexus; ; primary oocyte; ; fossa; ; condyle; ; endothelial cell of lymphatic vessel; ; cumulus cell; ; secondary oocyte; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; carboxy-lyase activity; NAD+ binding; lyase activity; UDP-glucuronate decarboxylase activity;
Cellular component	integral component of membrane; Golgi cisterna membrane; Golgi apparatus; extracellular exosome; mitochondrion; membrane; cytoplasm;
Biological process	protein tetramerization; UDP-D-xylose biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	80146
	67883
	ENSG00000115652
	ENSMUSG00000057363
	Q8NBZ7
	Q91XL3
NM_001253875; NM_001253876; NM_025076; NM_001377504; NM_001377505;
	NM_001377506; NM_001377507; NM_001377508; NM_001377509
	NM_026430
NP_001240804; NP_001240805; NP_079352; NP_001364433; NP_001364434;
	NP_001364435; NP_001364436; NP_001364437; NP_001364438
	NP_080706; NP_001355216; NP_001355217; NP_001355218
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucuronic acid decarboxylase 1 is an enzyme that in humans is encoded by the UXS1 gene.^[5]^[6]

UDP-glucuronate decarboxylase (UGD; EC 4.1.1.35) catalyzes the formation of UDP-xylose from UDP-glucuronate. UDP-xylose is then used to initiate glycosaminoglycan biosynthesis on the core protein of proteoglycans.[supplied by OMIM]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115652 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057363 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
^ ^a ^b "Entrez Gene: UXS1 UDP-glucuronate decarboxylase 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115652 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057363 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid19027726-5] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.

[entrez-6] "Entrez Gene: UXS1 UDP-glucuronate decarboxylase 1".

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