Ub-AMC

Ubiquitin-AMC showing 7-amino-4-methylcoumarin bound to the C-terminus of ubiquitin

Ubiquitin-AMC is a fluorogenic substrate for a wide range of deubiquitinating enzymes (DUBs), including ubiquitin C-terminal hydrolases (UCHs) and ubiquitin specific proteases (USPs). It is a particularly useful reagent for the study of deubiquitinating activity where detection sensitivity or continuous monitoring of activity is essential.[1]