Ubiquitin-like protein

Ubiquitin family
Superposition of the structures of ubiquitin (PDB: 1UBQ​, green) and NEDD8 (PDB: 1NDD​, magenta)
Identifiers
SymbolUbiquitin
PfamPF00240
InterProIPR029071
SMARTSM00213
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Ubiquitin-like proteins (UBLs) are a family of small proteins involved in post-translational modification of other proteins in a cell, usually with a regulatory function. The UBL protein family derives its name from the first member of the class to be discovered, ubiquitin (Ub), best known for its role in regulating protein degradation through covalent modification of other proteins. Following the discovery of ubiquitin, many additional evolutionarily related members of the group were described, involving parallel regulatory processes and similar chemistry. UBLs are involved in a widely varying array of cellular functions including autophagy, protein trafficking, inflammation and immune responses, transcription, DNA repair, RNA splicing, and cellular differentiation.[1][2][3]

  1. ^ Cappadocia L, Lima CD (February 2018). "Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism". Chemical Reviews. 118 (3): 889–918. doi:10.1021/acs.chemrev.6b00737. PMC 5815371. PMID 28234446.
  2. ^ van der Veen AG, Ploegh HL (7 July 2012). "Ubiquitin-like proteins". Annual Review of Biochemistry. 81 (1): 323–57. doi:10.1146/annurev-biochem-093010-153308. PMID 22404627.
  3. ^ Welchman RL, Gordon C, Mayer RJ (August 2005). "Ubiquitin and ubiquitin-like proteins as multifunctional signals". Nature Reviews. Molecular Cell Biology. 6 (8): 599–609. doi:10.1038/nrm1700. PMID 16064136. S2CID 7373421.