Ubiquitin B

UBB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KHW, 2MBB, 2MRO, 2MSG, 4UEL, 4UF6, 4WLR, 4WUR, 4ZPZ, 5CAW, 3OJ3, 5DK8, 5CRA, 4ZFR, 5CVO, 3ZLZ, 4WHV, 4ZFT, 3ZNH, 5D0M, 2Y5B, 2KWV, 5D0K, 5DFL, 5CVM, 4WZP, 5EDV, 5CVN, 2KWU, 4XOF, 5BNB, 2N13, 4ZUX, 5IFR, 5IBK, 5KGF, 5JG6, 5K9P, 5E6J
Identifiers
Aliases	UBB, HEL-S-50, Ubiquitin B
External IDs	OMIM: 191339; MGI: 98888; HomoloGene: 75104; GeneCards: UBB; OMA:UBB - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	16,382,745 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	62,444,039 bp
RNA expression pattern
	Top expressed in
	pons; ; pars reticulata; ; pars compacta; ; endothelial cell; ; lateral nuclear group of thalamus; ; middle temporal gyrus; ; pancreatic ductal cell; ; external globus pallidus; ; bronchial epithelial cell; ; retinal pigment epithelium;
	Top expressed in
	neural tube; ; primary oocyte; ; blastocyst; ; mesencephalon; ; dentate gyrus of hippocampal formation granule cell; ; rhombencephalon; ; primary visual cortex; ; cerebellar cortex; ; superior frontal gyrus; ; hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein tag; ubiquitin protein ligase binding;
Cellular component	cytoplasm; endocytic vesicle membrane; cytosol; mitochondrion; neuron projection; nucleus; extracellular exosome; plasma membrane; nucleoplasm; soma; endosome membrane; extracellular space; mitochondrial outer membrane; endoplasmic reticulum quality control compartment; vesicle; endoplasmic reticulum membrane; host cell;
Biological process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of epidermal growth factor receptor signaling pathway; interstrand cross-link repair; nucleotide-excision repair, DNA damage recognition; positive regulation of canonical Wnt signaling pathway; tumor necrosis factor-mediated signaling pathway; regulation of type I interferon production; positive regulation of protein monoubiquitination; TRIF-dependent toll-like receptor signaling pathway; Fc-epsilon receptor signaling pathway; endosomal transport; global genome nucleotide-excision repair; NIK/NF-kappaB signaling; G2/M transition of mitotic cell cycle; stress-activated MAPK cascade; transforming growth factor beta receptor signaling pathway; macroautophagy; negative regulation of canonical Wnt signaling pathway; nucleotide-excision repair, DNA gap filling; error-free translesion synthesis; regulation of tumor necrosis factor-mediated signaling pathway; stimulatory C-type lectin receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; JNK cascade; regulation of transcription from RNA polymerase II promoter in response to hypoxia; nucleotide-excision repair, DNA incision; I-kappaB kinase/NF-kappaB signaling; innate immune response; Notch signaling pathway; neuron projection morphogenesis; regulation of mRNA stability; protein polyubiquitination; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; virion assembly; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; positive regulation of NF-kappaB transcription factor activity; anaphase-promoting complex-dependent catabolic process; negative regulation of type I interferon production; nucleotide-binding oligomerization domain containing signaling pathway; positive regulation of protein ubiquitination; intracellular transport of virus; regulation of proteasomal protein catabolic process; viral life cycle; MyD88-dependent toll-like receptor signaling pathway; error-prone translesion synthesis; MAPK cascade; regulation of mitochondrial membrane potential; fibroblast growth factor receptor signaling pathway; ion transmembrane transport; glycogen biosynthetic process; regulation of neuron death; positive regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; translesion synthesis; transcription-coupled nucleotide-excision repair; mitochondrion transport along microtubule; T cell receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; positive regulation of transcription by RNA polymerase II; regulation of signal transduction by p53 class mediator; positive regulation of epidermal growth factor receptor signaling pathway; Wnt signaling pathway; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision, 5'-to lesion; ERBB2 signaling pathway; Wnt signaling pathway, planar cell polarity pathway; nucleotide-excision repair, preincision complex assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; protein folding; negative regulation of G2/M transition of mitotic cell cycle; protein ubiquitination; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; entry of bacterium into host cell; transmembrane transport; regulation of necroptotic process; membrane organization; endoplasmic reticulum mannose trimming; cellular iron ion homeostasis; regulation of hematopoietic stem cell differentiation; protein targeting to peroxisome; male meiosis I; female meiosis I; male gonad development; female gonad development; cytokine-mediated signaling pathway; modification-dependent protein catabolic process; hypothalamus gonadotrophin-releasing hormone neuron development; adipose tissue development; fat pad development; interleukin-1-mediated signaling pathway; seminiferous tubule development; energy homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	7314
	22187
	ENSG00000170315
	ENSMUSG00000019505
	P0CG47
	P0CG49
NM_018955; NM_001281716; NM_001281717; NM_001281718; NM_001281719;
	NM_001281720
	NM_011664; NM_001313984
NP_001268645; NP_001268646; NP_001268647; NP_001268648; NP_001268649;
	NP_061828
	NP_001300913; NP_035794
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin is a protein that in humans is encoded by the UBB gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170315 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019505 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Webb GC, Baker RT, Fagan K, Board PG (Mar 1990). "Localization of the human UbB polyubiquitin gene to chromosome band 17p11.1-17p12". Am J Hum Genet. 46 (2): 308–15. PMC 1684968. PMID 2154095.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170315 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019505 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2154095-5] Webb GC, Baker RT, Fagan K, Board PG (Mar 1990). "Localization of the human UbB polyubiquitin gene to chromosome band 17p11.1-17p12". Am J Hum Genet. 46 (2): 308–15. PMC 1684968. PMID 2154095.

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