Ulinastatin

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Ulinastatin is a glycoprotein that is isolated from healthy human urine or synthetically produced and has molecular weight of 25 - 40kDa. It acts as a urinary trypsin inhibitor (UTI). Highly purified ulinastatin has been clinically used for the treatment of acute pancreatitis, chronic pancreatitis, Stevens–Johnson syndrome, burns, septic shock, and toxic epidermal necrolysis (TEN).

The drug is used in Japan, where its brand name is Miraclid, as well as in South Korea, China, and India. In India, where it is approved to treat severe sepsis and acute pancreatitis, it is marketed under the brand name Ulihope, Ulicrit-Liquid, Ulinase,U-Tryp in India. It is also known by the names Bikunin and Urinastatin. In China, where it is approved to treat acute pancreatitis, chronic recurrent pancreatitis and acute circulatory failure, it is marketed under the brand name Techpool Roan.