Porcine parvovirus (PPV), a virus in the species Ungulate protoparvovirus 1 of genus Protoparvovirus in the virus family Parvoviridae,[3] causes reproductive failure of swine characterized by embryonic and fetal infection and death, usually in the absence of outward maternal clinical signs. The disease develops mainly when seronegative dams are exposed oronasally to the virus anytime during about the first half of gestation, and conceptuses are subsequently infected transplacentally before they become immunocompetent. There is no definitive evidence that infection of swine other than during gestation is of any clinical or economic significance. The virus is ubiquitous among swine throughout the world and is enzootic in most herds that have been tested. Diagnostic surveys have indicated that PPV is the major infectious cause of embryonic and fetal death.[4][5][6][7][8] In addition to its direct causal role in reproductive failure, PPV can potentiate the effects of porcine circovirus type II (PCV2) infection in the clinical course of postweaning multisystemic wasting syndrome (PMWS).[9][10]
^Cartwright, S. F. & Huck, R. A. (1967). "Viruses isolated in association with herd infertility, abortions and stillbirths in pigs". Vet Rec. 81: 196–197.
^Mengeling, W. L, WL (1978b). "Prevalence of porcine parvovirus-induced reproductive failure: An abattoir study". J Am Vet Med Assoc. 172 (11): 1291–1294. PMID659307.
^Thacker, B. & Leman, A. D. (1978). "Evaluation of gravid uteri at slaughter for porcine parvovirus infection". Proc Int Congr Pig Vet Soc. 5: M–49.
^Vannier, P. & Tillon, J. P. (1979). "Diagnostic de certitude de l'infection à parvovirus dans les troubles de la reproduction de l'espèce porcine". Rec Med Vet. 155: 151–158.
^Krakowka, S; Ellis, J. A.; Meehan, B; Kennedy, S; McNeilly, F; Allan, G (2016). "Viral Wasting Syndrome of Swine: Experimental Reproduction of Postweaning Multisystemic Wasting Syndrome in Gnotobiotic Swine by Coinfection with Porcine Circovirus 2 and Porcine Parvovirus". Veterinary Pathology. 37 (3): 254–63. doi:10.1354/vp.37-3-254. PMID10810990. S2CID37008391.
^Opriessnig, T; Fenaux, M; Yu, S; Evans, R.B.; Cavanaugh, D; Gallup, J.M.; Pallares, F.J.; Thacker, E.L.; Lager, K.M.; Meng, X.J.; Halbur, P.G. (2004). "Effect of porcine parvovirus vaccination on the development of PMWS in segregated early weaned pigs coinfected with type 2 porcine circovirus and porcine parvovirus". Veterinary Microbiology. 98 (3–4): 209–20. doi:10.1016/j.vetmic.2003.11.006. PMID15036529.