Upper James Street, is an Upper City (mountain) arterial road in Hamilton, Ontario, Canada. It starts at the Claremont Access, a mountain-access road in the north, and extends southward towards the John C. Munro Hamilton International Airport where it then changes its name to the Hamilton Port Dover Plank Road, (Highway 6). It is a two-way street throughout. As with most of the "Upper" streets, their addresses start at roughly the point where their lower counterpart finishes just below the Escarpment and were originally labelled without the "Upper" prefix.
(Note: Highway 6 now uses a new alignment from Highway 403 to south of the Hamilton Airport, connecting with the southerly leg to Caledonia, the Grand River and Port Dover.)