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Uptown Memphis is a neighborhood located near downtown Memphis, Tennessee. In 1999, the Uptown Partnership renamed the historic North Memphis Greenlaw neighborhood "Uptown" in concert with a public-private revitalization effort that defined Uptown as one hundred city blocks east of the Wolf River and North of A.W. Willis Avenue. The historic Greenlaw section of this neighborhood consists of the thirty city blocks closest to the Wolf River (bordered by A.W. Willis Avenue to the south, North Seventh Street to the east, Keel Avenue and Chelsea Avenue to the north and the Wolf River to the west).
Areas adjacent to Uptown include St. Jude Children's Research Hospital and the Pinch District.