Uridine monophosphate synthase

UMPS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HKP, 2EAW, 2JGY, 2P1F, 2QCC, 2QCD, 2QCE, 2QCF, 2QCG, 2QCH, 2QCL, 2QCM, 2QCN, 2V30, 2WNS, 3BGG, 3BGJ, 3BK0, 3BVJ, 3DBP, 3EWU, 3EWW, 3EWX, 3EWY, 3EWZ, 3EX1, 3EX2, 3EX3, 3EX4, 3EX6, 3G3D, 3G3M, 3L0K, 3L0N, 3MI2, 3MO7, 3MW7, 4HIB
Identifiers
Aliases	UMPS, OPRT, uridine monophosphate synthetase
External IDs	OMIM: 613891; MGI: 1298388; HomoloGene: 319; GeneCards: UMPS; OMA:UMPS - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	124,749,273 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	33,787,408 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; gonad; ; islet of Langerhans; ; Achilles tendon; ; right lobe of liver; ; mucosa of transverse colon; ; gingival epithelium; ; stromal cell of endometrium; ; mucosa of esophagus;
	Top expressed in
	primitive streak; ; Paneth cell; ; fetal liver hematopoietic progenitor cell; ; condyle; ; endothelial cell of lymphatic vessel; ; fossa; ; yolk sac; ; epiblast; ; ureter; ; abdominal wall;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	lyase activity; carboxy-lyase activity; transferase activity; catalytic activity; glycosyltransferase activity; orotidine-5'-phosphate decarboxylase activity; orotate phosphoribosyltransferase activity; identical protein binding;
Cellular component	cytoplasm; cytosol; nucleus;
Biological process	female pregnancy; pyrimidine nucleotide biosynthetic process; UMP biosynthetic process; metabolism; nucleoside metabolic process; pyrimidine nucleoside biosynthetic process; 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; lactation; pyrimidine nucleobase biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	7372
	22247
	ENSG00000114491
	ENSMUSG00000022814
	P11172
	P13439
	NM_000373
	NM_009471; NM_001348087
	NP_000364
	NP_033497; NP_001335016
	Wikidata
View/Edit Human	View/Edit Mouse

The enzyme Uridine monophosphate synthase (EC 4.1.1.23, UMPS) (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) catalyses the formation of uridine monophosphate (UMP), an energy-carrying molecule in many important biosynthetic pathways.^[5] In humans, the gene that codes for this enzyme is located on the long arm of chromosome 3 (3q13).^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114491 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022814 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: UMPS uridine monophosphate synthase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)".
^ Qumsiyeh MB, Valentine MB, Suttle DP (Jul 1989). "Localization of the gene for uridine monophosphate synthase to human chromosome region 3q13 by in situ hybridization". Genomics. 5 (1): 160–2. doi:10.1016/0888-7543(89)90103-1. PMID 2767686.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114491 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022814 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: UMPS uridine monophosphate synthase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)".

[pmid2767686-6] Qumsiyeh MB, Valentine MB, Suttle DP (Jul 1989). "Localization of the gene for uridine monophosphate synthase to human chromosome region 3q13 by in situ hybridization". Genomics. 5 (1): 160–2. doi:10.1016/0888-7543(89)90103-1. PMID 2767686.

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