Uromodulin

UMOD
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUMOD, ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP, uromodulin, ADTKD1
External IDsOMIM: 191845; MGI: 102674; HomoloGene: 2522; GeneCards: UMOD; OMA:UMOD - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278605
NM_009470

RefSeq (protein)

NP_001265534
NP_033496

Location (UCSC)Chr 16: 20.33 – 20.36 MbChr 7: 119.06 – 119.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Uromodulin (UMOD), also known as Tamm–Horsfall protein (THP), is a zona pellucida-like domain-containing glycoprotein that in humans is encoded by the UMOD gene.[5][6] Uromodulin is the most abundant protein excreted in ordinary urine.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169344Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030963Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jeanpierre C, Whitmore SA, Austruy E, Cohen-Salmon M, Callen DF, Junien C (March 1993). "Chromosomal assignment of the uromodulin gene (UMOD) to 16p13.11". Cytogenetics and Cell Genetics. 62 (4): 185–7. doi:10.1159/000133470. PMID 8382593.
  6. ^ "Entrez Gene: UMOD uromodulin (uromucoid, Tamm–Horsfall glycoprotein)".
  7. ^ Lau WH, Leong WS, Ismail Z, Gam LH (August 2008). "Qualification and application of an ELISA for the determination of Tamm Horsfall protein (THP) in human urine and its use for screening of kidney stone disease". International Journal of Biological Sciences. 4 (4): 215–22. doi:10.7150/ijbs.4.215. PMC 2500153. PMID 18695745.