Uroporphyrinogen III decarboxylase

UROD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JPH, 1JPI, 1JPK, 1R3Q, 1R3R, 1R3S, 1R3T, 1R3V, 1R3W, 1R3Y, 1URO, 2Q6Z, 2Q71, 3GVQ, 3GVR, 3GVV, 3GVW, 3GW0, 3GW3
Identifiers
Aliases	UROD, PCT, UPD, uroporphyrinogen decarboxylase
External IDs	OMIM: 613521; MGI: 98916; HomoloGene: 320; GeneCards: UROD; OMA:UROD - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.1 Start 45,010,950 bp[1] End 45,015,575 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D1|4 53.41 cM Start 116,847,162 bp[2] End 116,851,610 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone parotid gland right adrenal gland right adrenal cortex parietal pleura left adrenal cortex endothelial cell middle temporal gyrus Brodmann area 23 bone marrow Top expressed in fetal liver hematopoietic progenitor cell internal carotid artery endocardial cushion human fetus external carotid artery facial motor nucleus atrioventricular valve Epithelium of choroid plexus medullary collecting duct renal corpuscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding lyase activity uroporphyrinogen decarboxylase activity carboxy-lyase activity Cellular component nucleoplasm cytoplasm cytosol Biological process protoporphyrinogen IX biosynthetic process porphyrin-containing compound biosynthetic process heme biosynthetic process heme metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7389 22275 Ensembl ENSG00000126088 ENSMUSG00000028684 UniProt P06132 P70697 RefSeq (mRNA) NM_000374 NM_009478 RefSeq (protein) NP_000365 NP_033504 Location (UCSC) Chr 1: 45.01 – 45.02 Mb Chr 4: 116.85 – 116.85 Mb PubMed search [3] [4]
Wikidata
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Uroporphyrinogen III decarboxylase (uroporphyrinogen decarboxylase, or UROD) is an enzyme (EC 4.1.1.37) that in humans is encoded by the UROD gene.^[5]